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A C4ST-1 construct was designed and expressed in both Escherichia coli and Pichia pastoris in its non-glycosylated and glycosylated forms. Both constructs showed similar activity albeit different kinetic parameters when acting on a microbially prepared unsulfated chondroitin substrate. Moreover, the glycosylated form of C4ST-1 showed lower stability than the non-glycosylated form.
data demonstrate that the hip osteoarthritis susceptibility is mediated by differential protein binding to the alleles of rs835487 and rs835488, which are located within an enhancer whose target may be CHST11 during chondrogenesis or an alternative gene.
These results have demonstrated that CHST11 and CHST13 (show CHST13 Proteins) negatively modulate metastasis and drug resistance of HCC (show FAM126A Proteins) cells probably via oncogenic MAPK (show MAPK1 Proteins) signal pathway.
We conclude that CHSTs involved in the synthesis of CS-A and CS-E might influence ovarian cancer progression, and we suggest CHST11 as independent unfavorable prognostic factor in this entity.
CHST11 may play a direct role in progression of breast cancer and that its expression is controlled by DNA methylation (show HELLS Proteins). Therefore, in addition to CHST11 mRNA levels, the methylation status of this gene also has potential as a prognostic biomarker.
Silencing Wnt9A (show WNT9A Proteins) increased the expression of CHST11 in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A (show WNT9A Proteins) siRNA and exogenous BMP4 (show BMP4 Proteins) on the CHST11 promoter
reduced C4ST-1 expression and chondroitin sulfation imbalance mediating the effects of oncogenic HRAS (show HRAS Proteins) signaling in the pathogenesis of Costello syndrome.
Cell surface P-selectin (show SELP Proteins) binding depends on CHST11 gene expression. CSPG4 (show MCSP Proteins) serves as a P-selectin (show SELP Proteins) ligand through its CS chain and participates in P-selectin (show SELP Proteins) binding to the highly metastatic breast cancer cells.
Forced expression of C4ST-1 in L-Wnt-3a (show WNT3A Proteins) cells inhibited diffusion of Wnt-3a (show WNT3A Proteins) due to structural alterations in CS chains mediated by C4ST-1.
identified TGFbeta (show TGFB1 Proteins)- responsive regulatory modules that can function in a cell type-specific fashion. Taken together, our results identify TGFbeta (show TGFB1 Proteins)-dependent and -independent cis (show CISH Proteins)-regulatory modules of the C4ST-1 gene
Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling controls C4ST-1 gene expression through histone deacetylase (show HDAC1 Proteins). C4ST-1 expression is regulated through DNA sequence located at -394 and -387 in its promoter region.
Deficiency in Chst11 did not influence neural stem cell proliferation, migration or differentiation.
these results suggested that C4ST-1 and ChGn-2 (show CSGALNACT2 Proteins) may be involved in the elongation of chondroitin sulfate chains in the arterial wall during the progression of atherosclerosis.
a gene was identified for Chondroitin-4-sulfotransferase and displays a highly specific temporal and spatial expression pattern during mouse embryogenesis
chondroitin 4-O-sulfation by C4st1 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
results suggest that C4ST-1 regulates the expression of the E disaccharide unit and the length of CS chains, the features that facilitate infection of cells by HSV-1
CS-E-like (show TBCEL Proteins) structures synthesized by C4ST-1 participate in Wnt-3a (show WNT3A Proteins) signaling and modulate the physiological events caused by Wnt-3a (show WNT3A Proteins) signals.
expression of the Serglycincore protein, chondroitin 4-sulfotransferase (C4ST)-1, and GalNAc(4S)-6-O-sulfotransferase (GalNAc4S6ST (show CHST15 Proteins)) are closely linked to mast cell maturation
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12\;14)(q23\;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IgH/CHST11 fusion
, carbohydrate sulfotransferase 11
, chondroitin 4-O-sulfotransferase 1
, chondroitin 4-sulfotransferase 1
, chondroitin 4