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We have identified two enzymes of the human glycosyltransferase (show GTDC2 Proteins) 8 family, now named GXYLT1 and GXYLT2 (show GXYLT2 Proteins) (glucoside xylosyltransferase), as UDP-d-xylose:beta-d-glucoside alpha1,3-d-xylosyltransferases adding the first xylose.
GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF\; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010
glycosyltransferase 8 domain containing 3
, glycosyltransferase 8 domain-containing protein 3