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These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development.
RHAMM localises at the mitotic spindle of ovarian granulosa cells via its C-terminus, deletion of which impairs proper spindle orientation and folliculogenesis.
RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
Hyaluronon acid activation of RHAMM significantly impacts smooth muscle cell-ECM adhesive interactions and contributes to constrictive artery wall remodeling in mice.
This study demonistrated that Rhamm expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.
Overexpressing RHAMM was located intracellular and activated ERK1/2.
Results suggest that the CD44 and RHAMM receptors function on membrane lipid rafts during Cryptococcus neoformans invasion.
RHAMM isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis.
intracellular RHAMM(Delta163) functions as an adaptor protein to control microtubule polymerization during interphase and mitosis as a result of localizing ERK1/2-MEK1 complexes to their tubulin-associated substrates
Gene deletion of Rhamm attenuates the formation of aggressive fibromatosis.
CD44 and RHAMM are molecularly redundant and have roles in a model of arthritis and inflammation
Androgen receptor regulates CD168 expression and signaling in prostate cancer
IHABP/RHAMM mediates cytoplasmic anchoring of the transcription factor Bach1
It has shown that RHAMM-target peptides induced apoptosis and inhibited necrosis of tumor cells. RHAMM-target peptide had no effect on fibroblasts (non-tumor cells) and fibroblasts (RHAMM-/-).
BACH1 performs stabilization of mitotic spindle orientation together with HMMR and CRM1 in mitosis, and that the cell cycle-specific phosphorylation switches the transcriptional and mitotic functions of BACH1.
A mechanism of sense-antisense interference between HMMR and HMMR-AS1 in GBM.
This pilot study shows, for the first time, that RHAMM may contribute to ovarian cancer disease and could potentially be used as a prognostic marker.
The ability to enhance cell polarity through the application of this dielectrophoretic (DEP) electromagnetic field (EMF) force may offer another way to stabilize HMMR and differentially modulate its expression in cancerous and noncancerous cells.
we found that RHAMM-specific T cells are present at vaccination sites in AML patients. Our findings implicate that we and others who are using classical mo-DCs for cancer immunotherapy are already vaccinating against RHAMM.
RHAMM, most likely RHAMMv3 (RHAMMB), can serve as a prognostic factor for lung adenocarcinomas and a potential therapeutic target in non-small cell lung carcinoma to inhibit tumor migration
Data show that receptor of hyaluronan-mediated motility (RHAMM) mRNA expression in breast cancer biopsies is inversely correlated with tumor grade and overall survival.
spindle-associated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initiation of testicular germ cell tumors (TGCT).
Overexpression of the hyaluronan receptor HMMR in primary LUAD was associated with an inflammatory molecular signature and poor prognosis. Attenuating HMMR in LUAD cells diminished their ability to initiate lung tumors and distant metastases.
The present study suggests that RHAMM is a novel beta-catenin intracellular binding partner, protecting beta-catenin from degradation and supporting the nuclear translocation of this key cellular mediator
RHAMM expression identifies an aggressive subpopulation of tumor budding cells and is an independent adverse prognostic factor for colorectal cancer patients.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Identify RHAMM as a critical regulator of TPX2 location/ Aurora kinase A signaling and suggest that RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways.
In ocular TM cells, our data suggests that the most important determinant of HA cable formation appears to be the ratio of HA chains produced by the different HAS genes.
RHAMM might be a promising marker to identify early stage (nodal negative) patients at risk for dismal survival, who may benefit from specific adjuvant therapies.
analysis of the role of growth factors in Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis [review]
Case Report: identify patient with cervical cancer expressing three HMMR mRNA variants.
RHAMM may be implicated in severe ocular surface inflammation affecting the upper tarsal conjunctiva.
stimulation of the E2F1-RHAMM axis in aggressive cancer cells is of high clinical significance
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
hyaluronan mediated motility receptor
, intracellular hyaluronic acid-binding protein
, receptor for hyaluronan-mediated motility
, hyaluronan-mediated motility receptor