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Human ITIH1 Protein expressed in Wheat germ - ABIN1308229
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion
In a sepsis model inter-alpha-trypsin inhibitor inhibits complement activation through the classical and alternative pathways, inhibits complement-dependent phagocytosis in vitro, and reduces complement-dependent lung injury in vivo.
Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix.
Data suggest that Mg2 (show MUC7 Proteins)+ or Mn2+ (but not Ca2 (show CA2 Proteins)+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2 (show ITIH2 Proteins)) and a bikunin (show AMBP Proteins)/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin (show AMBP Proteins) binds adjacent to the two heavy chains.
The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population.
Data indicate that TSG-6 (show TNFAIP6 Proteins)-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6 (show TNFAIP6 Proteins)-mediated enhancement of HA binding to CD44 (show CD44 Proteins)-positive cells.
Human inter-alpha-inhibitor is a substrate for factor XIIIa (show F13A1 Proteins) and tissue transglutaminase (show TGM2 Proteins).
The first systematic analysis on the differential expression of ITIH genes in human cancer, showing frequent downregulation that may be associated with initiation and/or progression of these malignancies.
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
ITI heavy chain H1
, inter-alpha (globulin) inhibitor, H1 polypeptide
, inter-alpha-inhibitor heavy chain 1
, inter-alpha-trypsin inhibitor heavy chain H1
, inter-alpha (globulin) inhibitor H1
, inter-alpha-trypsin inhibitor complex component III
, serum-derived hyaluronan-associated protein
, inter-alpha-trypsin inhibitor heavy-chain H1