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Human PIM1 ELISA Kit for Sandwich ELISA - ABIN820482
Renard, Paulin, Breuils-Bonnet, Simard, Pibarot, Bonnet, Provencher: Pim-1: A new biomarker in pulmonary arterial hypertension. in Pulmonary circulation 2013
Results show that PIM1 is overexpressed in breast cancer tumors and provide evidence for its role in tumor resistance to PI3K (show PIK3CA ELISA Kits) inhibitors.
These results demonstrate the involvement of PIM kinases in LIF (show LIF ELISA Kits)-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Down-regulation of UHRF1 (show UHRF1 ELISA Kits) is an important mechanism of PIM1-mediated cellular senescence.
PIM kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival.
Triple negative breast cancer cells, but not nonmalignant mammary epithelial cells, were dependent on PIM1 for proliferation and protection from apoptosis.
PIM1 expression was higher in triple negative breast tumors than in estrogen and progesterone receptor (show PGR ELISA Kits) positive tumors.
High PIM1 expression is associated with osteosarcoma.
downregulation of PIM1 led to suppression of cell proliferation by cell cycle arrest at G1 phase and suppression of cell invasion and migration.
Pim-1L protects hepatic ABCA1 (show ABCA1 ELISA Kits) from lysosomal degradation by facilitating the physical interaction between ABCA1 (show ABCA1 ELISA Kits) and liver X receptor beta (show NR1H2 ELISA Kits) and subsequent stabilization of the ABCA1 (show ABCA1 ELISA Kits)-Pim-1L complex and thereby regulates the circulating level of high-density lipoprotein.
Furthermore, the Pim-1-HBP1 positive feedback loop exerts its effect by regulating the senescence markers DNMT1 and p16 and the apoptosis marker Bax. The Pim-1-HBP1 axis thus constitutes a novel checkpoint pathway critical for the inhibition of tumorigenesis.
this study shows that Pim-1 dysregulation has developmental-stage-specific effects on B lymphopoiesis and early myeloid, but not erythroid progenitors
Results show that elevated miR (show MLXIP ELISA Kits)-15b as an early response to Dicer (show DICER1 ELISA Kits) depletion silenced Pim-1 kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer (show DICER1 ELISA Kits)-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Pim1 kinase activity maintains airway epithelial integrity and protects against house dust mite-induced proinflammatory activation of the airway epithelium.
Pim kinases prevent premature cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics.
Pim-1 kinase activity regulates hepatocyte growth factor (show HGF ELISA Kits)-induced tumor cell migration, invasion, and cell scattering.
these results identify Pim1 as a novel effector molecule sufficient to drive CD4 (show CD4 ELISA Kits)( ) alphabeta T-cell development and survival in the absence of gammac cytokine receptor (show LEPR ELISA Kits) signaling.
Our data suggest that Pim1 might contribute to progression rather than initiation in prostate neoplasia.
Loss of PIM1 is associated with abnormal hematopoietic phenotypes.
Pim-1 activity prevents Drp1 (show CRMP1 ELISA Kits) compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI
Inhibition of the Pim1 oncogene (show RAB1A ELISA Kits) results in diminished visual function.
Pim1 overexpression enhanced the effect of intramyocardial delivery of CSCs to infarcted porcine hearts.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
, pim-1 kinase 44 kDa isoform
, pim-1 oncogene (proviral integration site 1)
, proto-oncogene serine/threonine-protein kinase pim-1
, serine/threonine-protein kinase pim-1
, pim-1 oncogene
, non-specific serine/threonine protein kinase
, proto-oncogene serine/threonine-protein kinase Pim-1
, proviral integration site 1
, kinase pim-1
, proviral integration site 2
, serine/threonine-protein kinase Pim-1
, serine/threonine-protein kinase pim-2