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dPAPST2 may be involved in Hedgehog (show SHH ELISA Kits) and Decapentaplegic (show TGFb ELISA Kits) signaling by controlling the sulfation of heparan sulfate
The specifically up-regulated non-coding gene HULC in HepG2 cell line has some effects on the expression of its neighboring gene SLC35B3.
PAPS (show PAPSS1 ELISA Kits) transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status.
PAPST2 is a PAPS (show PAPSS1 ELISA Kits) transporter gene involved in the synthesis of sulfated (show SULF1 ELISA Kits) glycoconjugates in the colon
PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1 (show SLC35B2 ELISA Kits), PAPST2]
Sulfation of a variety of molecules, including glycoproteins, proteoglycans, and glycolipids, requires 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS), a high-energy form of the universal sulfate donor. SLC35B3 translocates PAPS from the cytosol or nucleus, where it is synthesized, to the Golgi lumen for use (Kamiyama et al., 2006
, solute carrier family 35 member B3
, 3' phosphoadenosine 5' phosphosulfate transporter 2
, 3'-phosphoadenosine 5'-phosphosulfate transporter
, PAPS transporter 2
, adenosine 3'-phospho 5'-phosphosulfate transporter 2
, solute carrier family 35, member B3