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|Antigen||Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus), Monkey Alternatives|
|Conjugate||This BMPR2 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-BMPR2 AntibodyTarget Details BMPR2 Application Details Handling References for anti-BMPR2 antibody (ABIN965687) Images
|Immunogen||Purified recombinant fragment of human BMPR2 expressed in E. Coli.|
|Plasmids, Primers & others|
Target Details BMPR2Product Details anti-BMPR2 Antibody Application Details Handling References for anti-BMPR2 antibody (ABIN965687) Images back to top
|Alternative Name||BMPR2 (BMPR2 Antibody Abstract)|
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Synonyms: BMR2, PPH1, BMPR3, BRK-3, TALK, BMPR-II, FLJ41585, FLJ76945, BMPR2
|Pathways||Growth Factor Binding|
Application DetailsProduct Details anti-BMPR2 Antibody Target Details BMPR2 Handling References for anti-BMPR2 antibody (ABIN965687) Images back to top
Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BMPR2 Antibody Target Details BMPR2 Application Details References for anti-BMPR2 antibody (ABIN965687) Images back to top
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
References for anti-BMPR2 antibody (ABIN965687)Product Details anti-BMPR2 Antibody Target Details BMPR2 Application Details Handling Images back to top
|Product cited in:||
Phillips, Poling, Phillips, Stanton, Austin, Cogan, Wheeler, Yu, Newman, Dietz, Loyd: "Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 5, pp. 359-65, 2008
Rosenzweig, Morse, Knowles, Chada, Khan, Roberts, McElroy, Juskiw, Mallory, Rich, Diamond, Barst: "Clinical implications of determining BMPR2 mutation status in a large cohort of children and adults with pulmonary arterial hypertension." in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Vol. 27, Issue 6, pp. 668-74, 2008