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Human Polyclonal GLI1 Primary Antibody for ChIP, ELISA - ABIN153487
Ghali, Wong, Green, Tidman, Quinn: Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. in The Journal of investigative dermatology 1999
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Cow (Bovine) Polyclonal GLI1 Primary Antibody for WB - ABIN2779593
Rahnama, Shimokawa, Lauth, Finta, Kogerman, Teglund, Toftgård, Zaphiropoulos: Inhibition of GLI1 gene activation by Patched1. in The Biochemical journal 2006
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Human Polyclonal GLI1 Primary Antibody for IF (p), IHC (p) - ABIN673374
Zhang, Zhu, Zhou, Gao, Yuan, Han: Serotonin receptor 2C and insulin secretion. in PLoS ONE 2013
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Human Polyclonal GLI1 Primary Antibody for ICC, IF - ABIN4314249
Jalili, Mertz, Romanov, Wagner, Kalthoff, Stuetz, Pathria, Gschaider, Stingl, Wagner: NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo. in PLoS ONE 2013
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Shh (show SHH Antibodies) and Gli1 expression were associated with lymph node metastasis, TNM (show ODZ1 Antibodies) stage and tumor recurrence, suggesting Shh (show SHH Antibodies) and Gli1 protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma.
we have identified an oncogenic MALAT1-GLI1 fusion gene in all cases of gastroblastoma that may serve as a diagnostic biomarker.
Analysis of fibroblasts from a patient with homozygous C-terminal truncation of GLI1 demonstrated that the corresponding mutant GLI1 protein is fabricated by patient cells and becomes upregulated in response to Hh signaling.
The results showed that Shh (show SHH Antibodies) and Gli1 were upregulated in prostate cancer tissues and were targeted by a phytogenic neoplastic compound carnosol.
Our finding demonstrated that triple phosphorylation of GLI1 by AMPK (show PRKAA1 Antibodies) on Ser (show SIGLEC1 Antibodies)-102, Ser (show SIGLEC1 Antibodies)-408 and Thr (show TRH Antibodies)-1074 increases the cytoplasmic localization and binding stability to E3 ligase beta-TrCP (show BTRC Antibodies), ultimately driving GLI1 protein degradation.
Our results identify a new molecular mechanism involving miR (show MLXIP Antibodies)-326 and Arrb1 (show ARRB1 Antibodies) as regulators of Sonic hedgehog (show SHH Antibodies) medulloblastoma Cancer stem cells . Specifically, low levels of Arrb1 (show ARRB1 Antibodies) and miR (show MLXIP Antibodies)-326 trigger and maintain Hh/Gli signaling and self-renewal
study reveals that the USP48 (show USP48 Antibodies)-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis.
Gli-1 is a credible indicator for highly aggressive tumor with poor prognosis in gastric cancer patients [meta-analysis]
Gli1 promotes colorectal cancer cells metastasis in a Foxm1 (show FOXM1 Antibodies)-dependent manner by activating EMT (show ITK Antibodies) and PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling.
Gli may be critical for lung adenocarcinoma metastasis. A novel Gli inhibitor shows promise as a therapeutic agent by preventing cell migration and invasion in vitro and significantly reducing tumor growth and increasing E-Cadherin (show CDH1 Antibodies) expression in vivo.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 (show GLI2 Antibodies) in muscle were the lowest of the 13 tissues.
Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop (show SPOP Antibodies)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX Antibodies) inhibits Shh (show SHH Antibodies) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (show HMGCS1 Antibodies) had no effect on Shh (show SHH Antibodies) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (show SHH Antibodies) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 Antibodies) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Antibodies) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 (show KIF7 Antibodies) interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 (show KIF7 Antibodies) in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 (show GLI2 Antibodies) in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 (show GLI2 Antibodies) has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Antibodies)) factor activity.
FLT3 (show FLT3 Antibodies)-mutated in contrast to FLT3 (show FLT3 Antibodies) wildtype cells or normal human hematopoietic progenitor cells are exquisitely sensitive to combined inhibition by FLT3 (show FLT3 Antibodies), PI3K and GLI1/2 overcoming some of the limitations of current FLT3 (show FLT3 Antibodies) directed therapy in AML (show RUNX1 Antibodies).
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
Shh (show SHH Antibodies) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (show MITF Antibodies).
USP21 (show USP21 Antibodies) recruits and stabilises Gli1 at the centrosome.
High Gli1 expression is associated with leukemia.
Sufu (show SUFUH Antibodies) is upregulated in active Shh (show SHH Antibodies) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
NANOG (show NANOG Antibodies) binds to GLI1 and GLI3 (show GLI3 Antibodies) proteins and represses Hedgehog (show SHH Antibodies)-mediated transcription.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5