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anti-Human GLI1 Antibodies:
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Human Polyclonal GLI1 Primary Antibody for ChIP, ELISA - ABIN153487
Ghali, Wong, Green, Tidman, Quinn: Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. in The Journal of investigative dermatology 1999
Show all 31 Pubmed References
Cow (Bovine) Polyclonal GLI1 Primary Antibody for WB - ABIN2779593
Rahnama, Shimokawa, Lauth, Finta, Kogerman, Teglund, Toftgård, Zaphiropoulos: Inhibition of GLI1 gene activation by Patched1. in The Biochemical journal 2006
Show all 9 Pubmed References
Human Polyclonal GLI1 Primary Antibody for IF (p), IHC (p) - ABIN673374
Zhang, Zhu, Zhou, Gao, Yuan, Han: Serotonin receptor 2C and insulin secretion. in PLoS ONE 2013
Show all 7 Pubmed References
Human Polyclonal GLI1 Primary Antibody for ICC, IF - ABIN4314249
Jalili, Mertz, Romanov, Wagner, Kalthoff, Stuetz, Pathria, Gschaider, Stingl, Wagner: NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo. in PLoS ONE 2013
Show all 4 Pubmed References
HPI-1 worked more effectively than GANT-58 against breast carcinoma cells. In conclusion, HPI-1 could inhibit cell proliferation, reduce cell invasion and decrease cancer stem cell population in breast cancer cells. To target Gli-1 could be a potential strategy to suppress breast cancer stem cells.
High GLI1 expression is associated with unfavorable OS and FPS (show FDPS Antibodies) in patients with gastric cancer. As a member of the Hedgehog (show SHH Antibodies) signaling pathway, GLI1 co-expressed genes are also largely enriched in PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway in gastric cancer.
the results suggest that aberrant expression of Gli1 serves a role in HSCR (show EDNRB Antibodies) by targeting EDNRB (show EDNRB Antibodies).
High GLI1 expression is associated with Small Cell Lung Cancer.
Abnormal elevation of Gli1 and decrease of miR (show MLXIP Antibodies)-361 were found in esophageal cancer tissues. MiR (show MLXIP Antibodies)-361 weakened invasion of cancer cells and impeded EMT (show ITK Antibodies) process via the inhibition of Gli1.
Data show that miR (show MLXIP Antibodies)-150 inhibits glioma-associated oncogene homolog 1 (Gli1) expression via targeting 3'-UTR (show UTS2R Antibodies) of Gli1 gene.
Downregulation of miR (show MLXIP Antibodies)-150 and elevation of Gli1 promote the development and invasion of colorectal cancer cell Epithelial-mesenchymal transition (EMT (show ITK Antibodies)). MiR (show MLXIP Antibodies)-150 attenuated the progression of colorectal cancer cell EMT (show ITK Antibodies) via inhibiting Gli1.
data collectively suggest that silencing of PRMT1 (show PRMT1 Antibodies) exerts anti-catabolic and anti-inflammatory effects on IL-1beta (show IL1B Antibodies)-induced chondrocytes via suppressing the Gli-1 mediated Hedgehog (show SHH Antibodies) signaling pathway, indicating that PRMT1 (show PRMT1 Antibodies) plays a critical role in OA development and serves as a promising therapeutic target for OA.
Shh (show SHH Antibodies) and Gli1 expression were associated with lymph node metastasis, TNM (show ODZ1 Antibodies) stage and tumor recurrence, suggesting Shh (show SHH Antibodies) and Gli1 protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma.
we have identified an oncogenic MALAT1-GLI1 fusion gene in all cases of gastroblastoma that may serve as a diagnostic biomarker.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 (show GLI2 Antibodies) in muscle were the lowest of the 13 tissues.
Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX Antibodies) inhibits Shh (show SHH Antibodies) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (show HMGCS1 Antibodies) had no effect on Shh (show SHH Antibodies) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (show SHH Antibodies) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 Antibodies) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Antibodies) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 (show KIF7 Antibodies) interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 (show KIF7 Antibodies) in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 (show GLI2 Antibodies) in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 (show GLI2 Antibodies) has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Antibodies)) factor activity.
FLT3 (show FLT3 Antibodies)-mutated in contrast to FLT3 (show FLT3 Antibodies) wildtype cells or normal human hematopoietic progenitor cells are exquisitely sensitive to combined inhibition by FLT3 (show FLT3 Antibodies), PI3K and GLI1/2 overcoming some of the limitations of current FLT3 (show FLT3 Antibodies) directed therapy in AML (show RUNX1 Antibodies).
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
Shh (show SHH Antibodies) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (show MITF Antibodies).
USP21 (show USP21 Antibodies) recruits and stabilises Gli1 at the centrosome.
High Gli1 expression is associated with leukemia.
Sufu (show SUFUH Antibodies) is upregulated in active Shh (show SHH Antibodies) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
NANOG (show NANOG Antibodies) binds to GLI1 and GLI3 (show GLI3 Antibodies) proteins and represses Hedgehog (show SHH Antibodies)-mediated transcription.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5