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anti-Human GLI2 Antibodies:
anti-Rat (Rattus) GLI2 Antibodies:
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Human Polyclonal GLI2 Primary Antibody for IHC, WB - ABIN2777474
Ikram, Neill, Regl, Eichberger, Frischauf, Aberger, Quinn, Philpott: GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. in The Journal of investigative dermatology 2004
Show all 24 Pubmed References
Human Polyclonal GLI2 Primary Antibody for ChIP, ELISA - ABIN269891
Won, Kim, Lim, Sung, Kim, Park, Lee, Choi: Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma. in Pathology, research and practice 2015
Show all 4 Pubmed References
Human Polyclonal GLI2 Primary Antibody for ELISA - ABIN547626
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. in PLoS genetics 2005
Human Polyclonal GLI2 Primary Antibody for IHC, ELISA - ABIN129627
Roessler, Ermilov, Grange, Wang, Grachtchouk, Dlugosz, Muenke: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. in Human molecular genetics 2005
Human Polyclonal GLI2 Primary Antibody for IHC, WB - ABIN5516755
Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. in PLoS ONE 2016
Human Polyclonal GLI2 Primary Antibody for ICC, IF - ABIN4314278
Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen. in Experimental neurology 2015
Human Polyclonal GLI2 Primary Antibody for WB - ABIN3042988
Xiang, Jiang, Guo, Gong, Yang, Wu, Huang, Cheng, Xu: Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis. in Oncology reports 2014
Importantly, high expression levels of HIF-1alpha (show HIF1A Antibodies)/TGF-beta2 (show TGFB2 Antibodies)/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer.
Study found increased expression of GLI2 in osteosarcoma tissues and cell lines and determined that GLI2 is a target of miR (show MLXIP Antibodies)-141-3p.
In conclusion, our data suggest that overexpression of the Hedgehog (show SHH Antibodies) components SHH (show SHH Antibodies), GLI2 and FOXA2 (show FOXA2 Antibodies) might be used as markers of an aggressive hemangioma.
High GLI2 or PDGFRB expression is associated with unfavorable survival in GC patients. GLI2 can induce PDGFRB expression in GC cells via directly binding to its promoter. In addition, the GLI2-PDGFRB axis might be an important signaling pathway modulating CSC properties of GC cells.
Study report that compromised CSL (show CSHL1 Antibodies) function depends on GLI (show GLI1 Antibodies) activation for conversion of human dermal fibroblasts into CAFs (show TBX1 Antibodies), separately from cellular senescence. Decreased CSL (show CSHL1 Antibodies) upregulates the expression of the ULK3 (show ULK3 Antibodies) kinase, which binds and activates GLI2.
The authors found that hepatitis C virus derived from hepatitis C patients infected and directly induced the trans-differentiation of human primary fibroblasts into myofibroblasts, promoting fibrogenesis. This effect correlated with the activation of GLI2, one of the targets of Hedgehog (show SHH Antibodies) signaling pathway previously reported to be involved in myofibroblast generation.
role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer
This study showed associations of anorectal malformations with rs3738880 in GLI2 and with previous miscarriages.
High GLI2 expression is associated with hepatocellular carcinoma.
Hedgehog (show SHH Antibodies) pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI (show GLI1 Antibodies)-mediated activation of KIT expression.
Data indicate that the expression levels of transcription factors Gli1 (show GLI1 Antibodies) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 upregulation changed the cytokine expression profile in mouse pancreatic acinar cells, mainly decreasing the pro-inflammatory cytokines interleukin (IL)-6 (show IL6 Antibodies), interferon-gamma (show IFNG Antibodies), and FasL (show FASL Antibodies).
Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog (show SHH Antibodies) signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin (show INS Antibodies) sensitivity.
mice with single-allele Gli2 mutations exhibit increased penetrance and severity of Holoprosencephaly in response to low-dose teratogen exposure.
Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.
Gli2 and Gli3 (show GLI3 Antibodies) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (show GLI3 Antibodies) processing in Ta3 (show HSP90B1 Antibodies) mutant is at least in part due to a decrease in Gli2 and Gli3 (show GLI3 Antibodies) phosphorylation.
studies identify a novel molecular mechanism of regulation of CD40L (show CD40LG Antibodies) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 Antibodies) signaling
Sufu (show SUFUH Antibodies) is upregulated in active Shh (show SHH Antibodies) responding tissues and accompanies Gli (show GLI1 Antibodies) activators translocating into and Gli (show GLI1 Antibodies) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (show FADS1 Antibodies).
Despite increased production of full-length GLI2 and GLI3 (show GLI3 Antibodies) isoforms, previously identified GLI (show GLI1 Antibodies) targets important for mandibular and glossal development (Foxf1 (show FOXF1 Antibodies), Foxf2 (show FOXF2 Antibodies), Foxd1 (show FOXD1 Antibodies) and Foxd2 (show FOXD2 Antibodies)) were transcriptionally downregulated in Kif3a (show KIF3A Antibodies)(f/f);Wnt1 (show WNT1 Antibodies)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein