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novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease (show HTT Proteins).
Results show that pro-apoptotic Hippi-Hip-1 (show HIP1 Proteins) heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 (show HIP1 Proteins) and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway.
Hip-1 (show HIP1 Proteins) and Hippi cooperate to induce neuronal apoptosis in a caspase-8 (show CASP8 Proteins)-dependent manner.
Sonic hedgehog (Shh (show SHH Proteins)) pathway is downregulated in the neural tube in the absence of Hippi, which results in failure to establish ventral neural cell fate.
These findings suggest that Rybp (show RYBP Proteins) and Hippi may functionally interact in the apoptotic processes that accompany normal murine neural development.
sequencing of IFT57 in 13 OFDS subjects and 12 subjects with Ellis-Van Creveld syndrome (show EVC Proteins) was negative. This report identifies the implication of IFT57 in human pathology and highlights the first description of a ciliary transport defect in OFDS, extending the genetic heterogeneity of this subgroup of ciliopathies.
HIPPI-P53 (show TP53 Proteins) interaction was necessary for HIPPI mediated up-regulation of Caspase1 (show CASP1 Proteins) gene.
critical for the death-promoting effects of mutant huntingtin (show HTT Proteins) protein in cultured cells
Hippi interacts with the viral death protein Apoptin.
Hippi expression induced apoptosis by releasing AIF (show AIFM1 Proteins) and cytochrome c (show CYCS Proteins) from mitochondria, activation of caspase-1 (show CASP1 Proteins) and caspase-3 (show CASP3 Proteins), and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II.
Crystals of the pDED (show PDE6D Proteins) of HIPPI were grown in space group P4(1), with unit-cell parameters a = b = 77.42, c = 33.31 A and a calculated Matthews coefficient of 1.88 A3 Da(-1 (show TPM2 Proteins)) (33% solvent content) with two molecules per asymmetric unit.
In summary, we showed that HIPPI could interact with the putative promoter sequence of caspase-1 (show CASP1 Proteins) and increased the expression of the downstream gene suggesting that HIPPI could act as transcription regulator.
Over-expression of BLOC1S2 (show BLOC1S2 Proteins) in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 (show BLOC1S2 Proteins) & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL.
Required for the formation of cilia. May also have pro- apoptotic function (By similarity).
estrogen-related receptor beta like 1
, intraflagellar transport protein 57 homolog
, HIP1-interacting protein
, Vestrogen-related receptor beta like 1
, huntingtin-interacting protein-1 protein interactor
, intraflagellar transport 57 homolog
, HIP1 protein interactor
, dermal papilla-derived protein 8
, estrogen-related receptor beta-like protein 1
, huntingtin interacting protein-1 interacting protein