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anti-Human Patched 1 Antibodies:
anti-Rat (Rattus) Patched 1 Antibodies:
anti-Mouse (Murine) Patched 1 Antibodies:
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Human Polyclonal Patched 1 Primary Antibody for ICC, IHC (fro) - ABIN152262
Kaminagakura, Almeida, Carvalho, Franco, Soares, Rocha, Kowalski: Keratocyst of the buccal mucosa: case report and immunohistochemical comparative study with sporadic intraosseous keratocystic odontogenic tumor. in Oral surgery, oral medicine, oral pathology and oral radiology 2013
Show all 3 Pubmed References
Human Polyclonal Patched 1 Primary Antibody for ICC, IF - ABIN4343789
Estrada, Retting, Chin, Lyons: Smad6 is essential to limit BMP signaling during cartilage development. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011
Show all 2 Pubmed References
Human Polyclonal Patched 1 Primary Antibody for IHC, IHC (p) - ABIN4343793
Jeng, Sheen, Jeng, Yu, Hsiau, Chang: High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. in OncoTargets and therapy 2014
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Human Polyclonal Patched 1 Primary Antibody for IHC, ELISA - ABIN185521
Nagao, Togawa, Fujii, Uchikawa, Kohno, Yamada, Miyashita: Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarrays. in Human molecular genetics 2005
Show all 3 Pubmed References
Zebrafish (Danio rerio) Polyclonal Patched 1 Primary Antibody for ELISA - ABIN4237278
Laforest, Brown, Poleo, Géraudie, Tada, Ekker, Akimenko: Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays. in Development (Cambridge, England) 1998
Show all 2 Pubmed References
Human Polyclonal Patched 1 Primary Antibody for ELISA, IF - ABIN1585872
Gordon, Mansh, Kinsman, Morris: Xenopus sonic hedgehog guides retinal axons along the optic tract. in Developmental dynamics : an official publication of the American Association of Anatomists 2010
Mouse (Murine) Polyclonal Patched 1 Primary Antibody for CyTOF, FACS - ABIN4900555
Yaddanapudi, De Miranda, Hornig, Lipkin: Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. in PLoS ONE 2011
Human Monoclonal Patched 1 Primary Antibody for ICC, IF - ABIN4343790
Bolaños, Milla, Lira, Ramírez, Checa, Barrera, García-Alvarez, Carbajal, Becerril, Gaxiola, Pardo, Selman: Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. in American journal of physiology. Lung cellular and molecular physiology 2012
Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2 (show PTCH2 Antibodies)-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2 (show PTCH2 Antibodies)-/- mutants.
The Hedgehog (show SHH Antibodies) co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.
The generation and characterization of the ptc1;ptc2 (show PTCH2 Antibodies) double mutant assigned novel and unexpected functions to the Hh signaling pathway.
Positional cloning of blowout identified a nonsense mutation in patched1, a negative regulator of the Hedgehog (show SHH Antibodies) pathway, as the underlying cause of the blowout phenotype.
The authors found 15 germline PTCH1 mutations, uniformly distributed across the PTCH1 gene among patients with Basaloid Follicular Hamartoma and Basal Cell Carcinoma. Therefore, Basaloid Follicular Hamartoma and Basal Cell Carcinoma may be the same genetic entity and not two distinctive syndromes.
This study indicates that germline PTCH1 heterozygous mutations play a major role in bone metabolism in patients with NBCCS, in particular in those with PTCH1 protein truncation mutations. SPARC (show SPARC Antibodies) may represent an important downstream modulator of PTCH1 mediation of bone metabolism.
Demonstrate altered cytoplasmic expression of Ptc1 and reduced number and length of primary cilia, where Ptc1 is located, in fibroblasts from Niemann-Pick type C patients.
Nevoid basal cell carcinoma syndrome caused by splicing mutations in the PTCH1 gene.
PTCH1 expression is a promising molecular marker for predicting the imatinib response in chronic myeloid leukemia (show BCL11A Antibodies) patients in chronic phase.
the significant increase of blunt-ended, double-stranded DNA breaks, but not other types of DNA breaks, in normal cells from patients with RET/PTC (show RET Antibodies)-driven tumors suggests that blunt-ended double-stranded DNA breaks are a preferred substrate for rearrangement formation, and implicate involvement of the non-homologous end joining pathway in the formation of RET/PTC (show RET Antibodies) rearrangements.
Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction.
These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway.
epigenetic silencing of PTCH is a mechanism contributing to chronic lymphocytic leukemia tumorigenesis
PTCH1 mutations contribute to as much as 10% of ODA, identify the SHH (show SHH Antibodies) signaling pathway as a novel effector of SOX2 (show SOX2 Antibodies) activity during human ocular development, and indicate that ODA is likely the result of overactive SHH (show SHH Antibodies) signaling in humans harboring mutations in either PTCH1 or SOX2 (show SOX2 Antibodies).
study suggests that modifications affecting the Ptch1 cis (show CISH Antibodies)-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs
during Hedgehog (show SHH Antibodies) signaling, ligand binding inhibits Patched by trapping it in an inactive conformation, a mechanism that explains the dramatically reduced activity of oncogenic Patched1 mutants.
The seemingly simple, constitutive Hedgehog (show SHH Antibodies) response of patched/Ptch1 is driven by a complex regulatory architecture, with batteries of context-specific enhancers engaged in promoter-specific interactions to tune signaling individually in each tissue, without disturbing patterning elsewhere.
These findings support a model in which Ptch1/2 mediate secretion of a Smo-inhibitory cholesterol precursor.
Ptch1 required for ductal outgrowth and proper hormone receptor (show NR4A1 Antibodies) expression in the mammary epithelium.
Data indicate that Sonic hedgehog (Shh (show SHH Antibodies)) stimulate branching morphogenesis (BrM (show SMARCA2 Antibodies)) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF (show EGF Antibodies)) and receptors of the ErbB (show EGFR Antibodies) receptors ErbB1 (show EGFR Antibodies), ErbB2 (show ERBB2 Antibodies) and ErbB3 (show ERBB3 Antibodies).
Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53 (show TP53 Antibodies)-/- Hedgehog (show SHH Antibodies) (HH) pathway medulloblastoma.
Targeted single gene deletion of Ptch1 in mouse brain causes medulloblastoma.
Transcriptional upregulation of the inhibitory receptor Ptch1 regulates Shh (show SHH Antibodies) signaling during neural tube development.
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
, patched 1
, protein patched homolog 1
, patched homolog 1
, patched protein-like protein
, protein patched homolog 1-like
, patched protein
, patched-like protein
, PTCH protein +12b
, PTCH protein +4'
, PTCH protein -10
, PTCH protein -3,4,5
, patched homolog 2
, patched 2
, Patched 1
, Ptch1 protein +12b
, mesenchymal dysplasia