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The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT (show ITK Proteins)) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation.
These results establish PKR1 via NFATc3 (show NFATC3 Proteins) as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron.
show that MRAP2 significantly and specifically inhibits PKR1 signaling.
Data show that the prokineticins and their receptors PROK2 (show PROK2 Proteins), PKR1 and PKR2 (show PROKR2 Proteins) contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
These results suggest PKR1 to be a crucial player in the preadipocyte proliferation and differentiation.
Loss of PKR1 causes renal and cardiac structural and functional changes because of deficits in survival signaling, mitochondrial, and progenitor cell functions in found both organs.
The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 (show PROKR2 Proteins) levels and the divergent signaling pathways used by these receptors.
Identification and molecular characterization of two closely related G protein-coupled receptors (prokineticin receptor)
PKR1 protein was localised to the labyrinth layer and showed the same pattern of expression as EG-VEGF (show Prok1 Proteins) in mouse placenta.
Cardiomyocyte-PKR1 signaling upregulates its own ligand prokineticin-2 (show PROK2 Proteins) that acts as a paracrine factor, triggering epicardial-derived progenitor cell proliferation/differentiation.
a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
Data suggest that prokineticins (PROK1 (show Prok1 Proteins) and PROK2 (show PROK2 Proteins)) and prokineticin receptors (PROKR1 and PROKR2 (show PROKR2 Proteins)) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]
EG-VEGF (show Prok1 Proteins) and its receptor PKR1 might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease.
Expression of PROK1 (show Prok1 Proteins) and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk).
Study corroborates the clinical relevance of the EG-VEGF (show Prok1 Proteins) system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF (show Prok1 Proteins) and PROKR variants.
hCG (show CGA Proteins) increases EG-VEGF (show Prok1 Proteins), PROKR1 and PROKR2 (show PROKR2 Proteins) mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG (show CGA Proteins) in the regulation of EG-VEGF (show Prok1 Proteins) and its receptors
Findings, together with the detection of sequence variants in PROKR1, PROK1 (show Prok1 Proteins) and PROKR2 (show PROKR2 Proteins) genes associated to HSCR (show EDNRB Proteins) and, in some cases in combination with RET (show RET Proteins) or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR (show EDNRB Proteins).
The number of PKR1 is not reduced in preeclampsia.
Data suggest that smoking targets human Fallopian tubes via nAChRalpha-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to ectopic pregnancy.
Data show that expression of PK1 (show PKLR Proteins) and PKR1 was detected in primary MM cells and myeloma cell lines.
PROK1 (show Prok1 Proteins), acting via PROKR1, may be involved in the recruitment of monocytes to regressing CL and atretic follicles and their consequent activation therein.
G protein-coupled receptor for prokineticin
G protein-coupled receptor 73
, G-protein coupled receptor 73
, G protein-coupled receptor ZAQ
, G-protein coupled receptor ZAQ
, prokineticin receptor 1
, prokineticin receptor 1-like