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The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resista (show MAPK14 Proteins)nce to high-fat diet-induced obesity with increased energy expenditure.
Mouse and human heart valves expressed mRNAs for the CRL (show IL31RA Proteins) ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL (show IL31RA Proteins) and receptor-activity-modifying proteins 1-3.
ADM-2 is a stress-inducible gene controlled by ATF-4 (show ATF4 Proteins).
Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho (show KL Proteins) via the calcitonin receptor (show CALCR Proteins)/modifying protein complex and protein kinase A signaling.
Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury.
Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer.
ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 (show MMP2 Proteins) and decreasing MUC1 (show MUC1 Proteins) expression to facilitate trophoblast invasion.
Plasma intermedin and BNP levels were markedly higher in acute coronary syndrome patients than in healthy people.
High levels of ADM2 expression predict a poorer survival in patients with pancreatic adenocarcinoma.
TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries.
Intermedin attenuated neointima formation in the mouse model of common carotid-artery ligation injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway.
results indicate that endogenous AM2 might be involved in energy metabolism in adipocytes through the upregulation of UCP1 (show UCP1 Proteins) expression
ADM2 enhances subcutaneous White Adipose Tissue beiging via a direct effect by activating the CRLR.RAMP1-cAMP/PKA and p38 MAPK (show MAPK14 Proteins) pathways in white adipocytes and via an indirect effect by stimulating alternative M2 polarization in macrophages.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (show ADM Proteins) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
IMD reduces bone resorption by inhibiting osteoblast apoptosis, decreasing the RANKL/OPG (show TNFSF11 Proteins) ratio and the expression of M-CSF (show CSF1R Proteins), and inhibiting osteoclast maturation and differentiation.
Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space
Intermedin attenuates macrophage foam-cell formation via tristetraprolin (show ZFP36 Proteins)-mediated degradation of CD36 (show CD36 Proteins) mRNA.
increased stability of PTEN by intermedin leads to SR-A (show MSR1 Proteins) inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE (show APOE Proteins)(-/-) mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (show RAMP3 Proteins), but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR (show CALCRL Proteins)), and RAMP1 (show RAMP1 Proteins) and RAMP2 (show RAMP2 Proteins).
Intermedin is a calcitonin/calcitonin (show CALCA Proteins) gene-related peptide (show CALCA Proteins) family peptide acting through the calcitonin receptor-like receptor (show CALCRL Proteins)/receptor activity-modifying protein receptor complexes
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, adrenomedullin 2 precusor