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|Antigen||Calcitonin-Related Polypeptide alpha (CALCA) Antibodies|
|Conjugate||This CGRP antibody is un-conjugated Alternatives|
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Product Details anti-CGRP AntibodyTarget Details CGRP Application Details Handling Images
|Sequence||ACNTATCVTH RLAGLLSRSG GMVKSNFVPT NVGSKAF|
|Specificity||This antibody detects Calcitonin Gene-related Peptide. There were no cross reactivities obtained with human and salmon Katacalcin and Calcitonin.|
|Plasmids, Primers & others|
Target Details CGRPProduct Details anti-CGRP Antibody Application Details Handling Images back to top
|Alternative Name||CGRP / CALCA (CALCA Antibody Abstract)|
|Background||CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat, it can modulate acetylcholine receptor function at the neuromuscular junction, it has been demonstrated to block tolerance to morphine, and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I|
|Pathways||Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour|
Application DetailsProduct Details anti-CGRP Antibody Target Details CGRP Handling Images back to top
RIA (1: 3,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CGRP Antibody Target Details CGRP Application Details Images back to top
|Reconstitution||Restore in aqua bidest to initial volume.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store lyophilized at 2 - 8 °C and reconstituted at -20 °C.|