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High expression of LHRH is associated with ovarian cancer.
Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb (show FSHB Proteins) gene sensitivity to gonadotropin-releasing hormone pulse frequency
GNRH (and GNRHR (show GNRHR Proteins)) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.
High LHRH expression is associated with sarcomas of bone and soft tissue.
GnRH regulates trophoblast invasion via RUNX2 (show RUNX2 Proteins)-mediated MMP2 (show MMP2 Proteins)/MMP9 (show MMP9 Proteins) expression.
our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy.
Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review)
Data suggest differences in regulation of expression of PEDF (show SERPINF1 Proteins) (up-regulation) vs. VEGF (show VEGFA Proteins) (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR (show GNRHR Proteins) agonists rather than hCG (show CGA Proteins).
No abnormalities were found in the patient group for the PROKR2 (show PROKR2 Proteins) and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes
Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice.
Data (including data from studies in transgenic mice) suggest that Crh alters Gnrh neuron activity and that estradiol is required for Crh to exert both stimulatory and inhibitory effects on Gnrh neurons. (Crh = corticotropin-releasing hormone; Gnrh = gonadotropin releasing hormone)
Data suggest that expression of Rps6ka5 (show RPS6KA5 Proteins) in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga (show CGA Proteins) expression; GnRH-activates Rps6ka5 (show RPS6KA5 Proteins) targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5 (show RPS6KA5 Proteins)= mitogen and stress-activated protein kinase 1 (show RPS6KA5 Proteins); GnRH = gonadotropin-releasing hormone; Cga (show CGA Proteins) = gonadotropin alpha subunit (show POLG Proteins))
The studies in this manuscript describe specific histone modifications on the enhancer and promoter of the mouse GnRH (mGnRH) gene induced by kisspeptin in GnRH neuronal cell lines.
Nesfatin-1 increased Gnrh expression in hypothalamic and pituitary cells.
GnRH-E1 RNA is an inducer of Gnrh1 gene expression that may play an important role in the development and maturation of GnRH neurons
tet2 activity in GnRH neurons has influence over the neuroendocrine control of male reproductive function
Neurons in the hypothalamus produce Kiss1 and can synchronize their activity and activate GnRH neurons thus coordinating reproduction and fertility.
GnRH stimulated the secretion of the VGF (show VGF Proteins)-derived peptide NERP1 (show VGF Proteins). NERP1 (show VGF Proteins) caused a concentration-dependent decrease in Fshb (show FSHB Proteins) gene induction.
DHA and palmitate increase Gnrh enhancer-derived RNA levels.
findings suggest that GnRH is necessary for constitutive ANXA5 (show ANXA5 Proteins) expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types
Guinea pig GnRH is predominantly present in the brain and has a lower in vivo luteinizaing hormone (LH)-releasing activity than Gnrh of the rat.
findings report the changes in inhibin-alpha subunit gene expression in the corpus luteum is regulated by LH; results suggest a possible multiple crosstalk of Wnt, cAMP, and SF-1 in the regulation of luteal inhibin secretion
Posterior hypothalamic lesion animals had elevated LHRH levels and higher evening glutamate (show GRIN2C Proteins) levels after lesions, whereas LHRH changes did not occur in sham/controls until later.
Estradiol(E2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E2 appears to be mediated, in part, through GPR30 (show GPER Proteins).
These results suggest that social hierarchy regulates the expression of GnRH1, GnRH3, and Kiss1 (show KISS1 Proteins) without affecting 11-ketotestosterone level in male medaka.
Study detected several subpopulations of GnRH1 and GnRH3 neurons classified by their projection and distribution patterns using gnrh1:EGFP medaka and gnrh3:EGFP medaka
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene.
GnRH-associated peptide 1
, gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
, luliberin I
, progonadoliberin I
, prolactin release-inhibiting factor
, gonadotropin releasing hormone 2
, luteinizing hormone-releasing hormone I
, gonadotropin releasing hormone 1
, luteinizing hormone-releasing hormone
, chicken gonadotrophin releasing hormone-I
, gonadotrophin-releasing hormone I
, gonadotropin-releasing hormone associated peptide
, progonadoliberin-1 preproprotein
, Progonadoliberin I
, luliberin i
, luteinizing hormone
, luteinizing-releasing hormone
, Medaka-type gonadotropin-releasing hormone
, gonadotropin-releasing hormone
, medaka-type gonadotropin-releasing hormone
, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)