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Human Hepcidin ELISA Kit for Sandwich ELISA - ABIN415120
Cheng, Sun, Jiang, Tang, Jiao: Hepcidin expression in patients with acute leukaemia. in European journal of clinical investigation 2012
Show all 16 Pubmed References
Human Hepcidin ELISA Kit for Competition ELISA - ABIN2761946
Sany, Elsawy, Elshahawy: Hepcidin and regulation of iron homeostasis in maintenance hemodialysis patients. in Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2014
Show all 9 Pubmed References
Human Hepcidin ELISA Kit for Sandwich ELISA - ABIN457010
Jiang, Sun, Tang, Xu, Jiao: Hepcidin expression and iron parameters change in Type 2 diabetic patients. in Diabetes research and clinical practice 2011
Show all 8 Pubmed References
Mouse (Murine) Hepcidin ELISA Kit for Sandwich ELISA - ABIN415686
Shin, Chung, Joe, Pae, Chang, Cho, Ryter, Chung: Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways. in Blood 2012
Show all 6 Pubmed References
Rat (Rattus) Hepcidin ELISA Kit for Sandwich ELISA - ABIN416434
Huang, Chuang, Yang, Huang, Wu, Chen: Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation of signal transducer and activator of transcription 3 signaling. in Laboratory investigation; a journal of technical methods and pathology 2009
Show all 5 Pubmed References
Pig (Porcine) Hepcidin ELISA Kit for Competition ELISA - ABIN2761945
Pu, Guo, Liu, Xiong, Wang, Du: Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin. in Biological trace element research 2015
Show all 2 Pubmed References
Mouse (Murine) Hepcidin ELISA Kit for Competition ELISA - ABIN2761947
Vecchi, Montosi, Garuti, Corradini, Sabelli, Canali, Pietrangelo: Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. in Gastroenterology 2014
Show all 2 Pubmed References
Rat (Rattus) Hepcidin ELISA Kit for Sandwich ELISA - ABIN578992
Wang, Du, Duan, Guo, Sun, Liu: Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. in World journal of gastroenterology : WJG 2013
results suggest that lower Hepcidin-25, as well as higher sTfR and sTfR/Hepcidin-25 ratio were significant predictors of favorable hemoglobin response within a month after IV administration of ferric carboxymaltose in patients with CKD
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis (show HFE ELISA Kits) patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 (show TFR2 ELISA Kits) [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (show HFE ELISA Kits) (p.Tyr230Cys), and one mutation in the 5'-UTR (show UTS2R ELISA Kits) of HAMP gene (c.-25G>A)
increased intracellular iron content in recombinant-TfR1 (show TFRC ELISA Kits) HepG2 cells did not increase hepcidin responses compared to wild-type cells, resembling hemochromatosis (show HFE ELISA Kits)
Review of the role of hepcidin in iron metabolism disorders.
The bone morphogenetic protein (BMP) pathway regulates expression of hepcidin through transcriptional activation via BMP-responsive elements (REs) 1 and 2 on the promoter. A search for GC-rich sequences on the hepcidin promoter indicated 13 regions across the distal (A to F), middle (G to I), and proximal (J to M) areas.
Of the non-HFE (show HFE ELISA Kits) forms of iron overload, TFR2 (show TFR2 ELISA Kits)-, HFE2 (show HFE2 ELISA Kits)-, and HAMP-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (show SLC40A1 ELISA Kits) variants that have been previously associated with autosomal-dominant ferroportin (show SLC40A1 ELISA Kits) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Data (including data from studies using knockout mice) suggest that MT2 (show MT2 ELISA Kits)/TMPRSS6 (show TMPRSS6 ELISA Kits) suppresses hepcidin expression in hepatocytes independently of HJV (show HFE2 ELISA Kits); MT2 (show MT2 ELISA Kits)/TMPRSS6 (show TMPRSS6 ELISA Kits) cleaves ALK2 (show ACRV1 ELISA Kits), ALK3 (show BMPR1A ELISA Kits), ACTRIIA (show ACVR2A ELISA Kits), BMPR2 (show BMPR2 ELISA Kits), HFE (show HFE ELISA Kits), and, to a lesser extent, HJV (show HFE2 ELISA Kits) and TFR2 (show TFR2 ELISA Kits); thus, MT2 (show MT2 ELISA Kits)/TMPRSS6 (show TMPRSS6 ELISA Kits) suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway. (MT2 (show MT2 ELISA Kits)/TMPRSS6 (show TMPRSS6 ELISA Kits) = matriptase-2 (show TMPRSS6 ELISA Kits); HJV (show HFE2 ELISA Kits) = hemojuvelin (show HFE2 ELISA Kits))
two unrelated hepatocellular carcinoma patients bore the HAMP:c.-153C>T mutation at the heterozygous state, which is associated with increased risk of iron overload and severe hemochromatosis (show HFE ELISA Kits)
Hepcidin-25 released from plaque macrophages and other cell surfaces contributed to the plaque instability by inducing endothelial cell death.
Hepcidin plasma levels were increased in patients with early rheumatoid arthritis compared with healthy volunteers.
Anti-hemojuvelin (show HFE2 ELISA Kits) antibody corrects anemia caused by inappropriately high hepcidin levels
hepcidin mRNA upregulation depends on M1 macrophage polarization
Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD (show TSC2 ELISA Kits).
downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss.
These data suggest that, in Hjv (show HFE2 ELISA Kits)(-/-) females, Bmp6 (show BMP6 ELISA Kits) can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.
The authors generated mice with cardiomyocyte-specific deletion of hepcidin, or knock-in of hepcidin-resistant ferroportin (show SLC40A1 ELISA Kits). They find that while both models maintain normal systemic iron homeostasis, the mice nonetheless develop fatal contractile and metabolic dysfunction as a consequence of cardiomyocyte iron deficiency.
Erythroferrone and matriptase-2 (show TMPRSS6 ELISA Kits) independently regulate hepcidin expression.
Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 (show FKBP1A ELISA Kits) preferentially targets the BMP receptor (show BMPR1A ELISA Kits) ALK2 (show ACRV1 ELISA Kits). ALK2 (show ACRV1 ELISA Kits) mutants defective in binding FKBP12 (show FKBP1A ELISA Kits) increase hepcidin expression in a ligand-independent manner, through BMP-SMAD (show SMAD1 ELISA Kits) signaling.
Hamp1 mRNA and plasma hepcidin levels are not good predictors of tissue iron levels, at least in males
The lack of effect of erythropoietin (show EPO ELISA Kits) on hepcidin expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin (show EPO ELISA Kits) administration in both C57BL/6 and mask mice.
This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (show HFE2 ELISA Kits).
Hepcidin expression is regulated by a transferrin-a (show Tf ELISA Kits)-dependent pathway in the zebrafish embryo.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (show Tf ELISA Kits) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (show LEAP2 ELISA Kits))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide