anti-Rat (Rattus) Islet Amyloid Polypeptide antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Islet Amyloid Polypeptide Antibody (supplied by: Log in to see )

Antigen
Islet Amyloid Polypeptide (IAPP) Antibodies
  • DAP
  • IAP
  • LOC100230121
  • Amylin
  • islet amyloid polypeptide
  • IAPP
  • Iapp
Reactivity
Human, Mouse (Murine), Rat (Rattus)
106
20
11
9
6
4
3
3
1
1
1
1
1
Host
Rabbit
105
13
Clonality
Polyclonal
Conjugate
Un-conjugated
11
6
4
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
58
47
43
25
17
13
5
5
4
2
2
2
2
1
1
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Catalog No. ABIN271869
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN221316 IHC (fro) IHC (p) Rabbit IgG Log in to see Polyclonal 0
1 ABIN2607296 ICC IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal 0
1 ABIN115737 IHC (fro) IHC (p) Rabbit Log in to see Polyclonal 2
1 ABIN285658 IHC (fro) IHC (p) Rabbit IgG1 Log in to see Polyclonal 0

General

Antigen Islet Amyloid Polypeptide (IAPP) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(106), (20), (11), (9), (6), (4), (3), (3), (1), (1), (1), (1), (1)
Host Rabbit
(105), (13)
Clonality
Polyclonal
Conjugate Un-conjugated
(11), (6), (4), (1)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(58), (47), (43), (25), (17), (13), (5), (5), (4), (2), (2), (2), (2), (1), (1)
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Product details

Target Details Application Details Handling Images
Specificity This antibody detects endogenous levels of Amylin protein. (region surrounding His28)
Cross-Reactivity (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Purity > 95 % pure by SDS-PAGE

Target Details

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Antigen
Alternative Name Amylin / IAPP (IAPP Antibody Abstract)
Background Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide(CGRP), calcitonin (CT), and amylin are homologous polypeptides with overlapping biological actions such as vasodilatation and inhibition of bone resorption. Amylin (Islet/insulinoma amyloid polypeptide or IAPP) is a 37-amino acid monomeric polypeptide isolated from pancreatic amyloid. This protein, with a calculated molecular mass of 4 kDa, is a major component of amyloid-rich pancreatic extracts of three type 2 diabetic patients. IAPP has cysteine residues in positions 2 and 7, a feature found in all known calcitonin gene-related peptides. IAPP shows 46 % amino acid sequence homology with CGRP II. Since IAPP has been demonstrated immunochemically in normal beta cells of several mammals, it probably has an important role in respect to pancreatic islet function.Synonyms: Diabetes-associated peptide, Insulinoma amyloid peptide, Islet amyloid polypeptide
Molecular Weight approx. 10 kDa
Gene ID 3375
NCBI Accession NP_000406
UniProt P10997
Pathways Hormone Activity, Feeding Behaviour

Application Details

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Application Notes ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

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Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

Images

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Supplier Images
 image for anti-Islet Amyloid Polypeptide (IAPP) antibody (ABIN271869) anti-Islet Amyloid Polypeptide (IAPP) antibody
 image for anti-Islet Amyloid Polypeptide (IAPP) antibody (ABIN271869) anti-Islet Amyloid Polypeptide (IAPP) antibody (Image 2)