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|Antigen||Stanniocalcin 2 (STC2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This Stanniocalcin 2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-Stanniocalcin 2 AntibodyTarget Details Stanniocalcin 2 Application Details Handling References for anti-Stanniocalcin 2 antibody (ABIN356935) Images
|Specificity||This antibody detects STC2 at N-term.|
|Purification||Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||KLH conjugated synthetic peptide selected from the N-terminal region of human STC2|
Target Details Stanniocalcin 2Product Details anti-Stanniocalcin 2 Antibody Application Details Handling References for anti-Stanniocalcin 2 antibody (ABIN356935) Images back to top
|Alternative Name||Stanniocalcin 2 / STC2 (STC2 Antibody Abstract)|
|Background||STC2 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression is induced by estrogen and altered in some breast cancers.Synonyms: STC-2, STC-related protein, STCRP, Stanniocalcin-2, Stanniocalcin-related protein|
|Molecular Weight||33249 Da|
|Gene ID||8614, 9606|
|Pathways||Hormone Activity, ER-Nucleus Signaling|
Application DetailsProduct Details anti-Stanniocalcin 2 Antibody Target Details Stanniocalcin 2 Handling References for anti-Stanniocalcin 2 antibody (ABIN356935) Images back to top
ELISA1: 1,000. Western blotting 1: 100 - 1: 500. Immunohistochemistry: 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Stanniocalcin 2 Antibody Target Details Stanniocalcin 2 Application Details References for anti-Stanniocalcin 2 antibody (ABIN356935) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-Stanniocalcin 2 antibody (ABIN356935)Product Details anti-Stanniocalcin 2 Antibody Target Details Stanniocalcin 2 Application Details Handling Images back to top
DiMattia, Varghese, Wagner: "Molecular cloning and characterization of stanniocalcin-related protein." in: Molecular and cellular endocrinology, Vol. 146, Issue 1-2, pp. 137-40, 1999
Ishibashi, Miyamoto, Taketani, Morita, Takeda, Sasaki, Imai: "Molecular cloning of a second human stanniocalcin homologue (STC2)." in: Biochemical and biophysical research communications, Vol. 250, Issue 2, pp. 252-8, 1998
ImagesProduct Details anti-Stanniocalcin 2 Antibody Target Details Stanniocalcin 2 Application Details Handling References for anti-Stanniocalcin 2 antibody (ABIN356935) back to top