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Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. (Stanniocalcin-2)
Results show that STC2 promotes head and neck squamous cell carcinoma cell proliferation, tumor growth, and metastasis through the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/Snail (show SNAI1 Proteins) pathway.
STC2 promotes colorectal cancer tumorigenesis and epithelial-mesenchymal transition (EMT (show ITK Proteins)) progression through activating ERK (show EPHB2 Proteins)/MEK (show MAP2K1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathways.
Our results demonstrated the contrasting effects of STC1 (show STC1 Proteins) and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 (show ACAT1 Proteins) expression and on HASMC migration.
Mus81 (show MUS81 Proteins) knockdown suppresses proliferation and survival of HCC (show FAM126A Proteins) cells likely by downregulating STC2 expression, implicating Mus81 (show MUS81 Proteins) as a therapeutic target for HCC (show FAM126A Proteins).
These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK (show EPHB2 Proteins) activation
STC2 is involved in regulating PAPP-A (show PAPPA Proteins) activity during the development of atherosclerosis
Data suggest that stanniocalcin 1 (show STC1 Proteins) and 2 (STC1 (show STC1 Proteins), STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A (show PAPPA Proteins)) during folliculogenesis.
Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways.
The results showed that the expression of HMGA2 and STC2 was positively correlated. Furthermore, STC2 expression was significantly associated with tumor grade and histotype.
This study utilized ER+ IBC to identify a metagene including ABAT (show ABAT Proteins) and STC2 as predictive biomarkers for endocrine therapy resistance.
results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation
Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function.
The Stc2 promoter contains multiple putative xenobiotic response elements.
These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho (show KL Proteins)-Fgf23 (show FGF23 Proteins) signaling may contribute to limitation of ectopic calcification.
These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2 (show CA2 Proteins)+ homeostasis by mammalian STC2.
STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury.
induced STC2 expression is an essential feature of survival component of the unfolded-protein response
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
, STC-related protein
, stanniocalcin-related protein