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Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. (Stanniocalcin-2)
STC2, is a possible early marker during development of diabetes mellitus.
In STEMI patients, Stanniocalcin-2 and IGFBP-4 emerged as independent predictors of all-cause death and readmission due to HF. The Stanniocalcin-2/PAPP-A/IGFBP-4 axis exhibits a significant role in STEMI risk stratification.
MiR-184 was confirmed to directly target STC2 in glioblastoma cells
Results show that STC2 promotes head and neck squamous cell carcinoma cell proliferation, tumor growth, and metastasis through the PI3K/AKT/Snail pathway.
STC2 promotes colorectal cancer tumorigenesis and epithelial-mesenchymal transition (EMT) progression through activating ERK/MEK and PI3K/AKT signaling pathways.
Our results demonstrated the contrasting effects of STC1 and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration.
Mus81 knockdown suppresses proliferation and survival of HCC cells likely by downregulating STC2 expression, implicating Mus81 as a therapeutic target for HCC.
These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK activation
STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis
Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis.
Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways.
The results showed that the expression of HMGA2 and STC2 was positively correlated. Furthermore, STC2 expression was significantly associated with tumor grade and histotype.
This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance.
STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC/Claudin-1-mediated signaling in human breast cancer cells.
STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer
The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients.
Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer.
These findings suggest that STC2 can be a potential lung cancer biomarker and plays a positive role in lung cancer metastasis and progression.
Circulating STC1 and STC2 mRNA are potentially useful blood markers for LSCC
High STC2 expression is associated with glioma.
results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation
Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function.
The Stc2 promoter contains multiple putative xenobiotic response elements.
These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho-Fgf23 signaling may contribute to limitation of ectopic calcification.
These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2+ homeostasis by mammalian STC2.
STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury.
induced STC2 expression is an essential feature of survival component of the unfolded-protein response
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
, STC-related protein
, stanniocalcin-related protein