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General |
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Antigen | Vasoactive Intestinal Peptide (Vip) Antibodies |
Reactivity | Bat, Bird (Avian), Bream (Sparus aurata), Buffalo (Bubalus), Bullfrog (Rana catesbeiana), Cat (Feline), Chicken, Columbina passerina (Common ground-dove), Cryptomys amatus (Mole rat), Dasyatis akajei (Red stingray) (Trygon akajei), Dog (Canine), Duckbill (Platypus), Fish, Fox, Frog, Goldfish, Guinea Pig, Guineafowl, Hamster, Hedgehog (Erinaceinae), Human, Lamprey, Lizard, Marine Mollusks (Liolophura), Mink, Monkey, Mouse (Murine), Mudpuppy (Necturus), Opossum (Didelphimorphia), Pig (Porcine), Pigeon, Rabbit, Raccoon (Procyon lotor), Rat (Rattus), Sheep (Ovine), Shrew, Snake, Sparrow, Squirrel, Starfish (Marthasterias), Suncus murinus, Turkey, Turtle, Worm (Spionidae), Zebra finch (Taeniopygia guttata), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | Un-conjugated Alternatives |
Application |
Immunoelectron Microscopy (IEM), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
Alternatives
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496 references available |
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Cross-Reactivity | Mammalian |
Characteristics | The antibody has a proven strong fluorescent staining at a 1/200-1/400 dilution and a strong Biotin-Streptavidin/HRP staining at a 1/4000-1/6000 dilution in rat amygdala, cortex, and suprachiasmatic nucleus. The specificity of the antiserum was examined by soluble pre-adsorption with the peptides in question at a final concentration of 10-5 M. VIP immunolabeling was completely abolished by pre-adsorption with VIP. Pre-adsorption with the following peptides resulted in no reduction of immunostaining: Secretin, gastric inhibitory polypeptide, somatostatin, glucagon, insulin, ACTH, gastrin 34, FMRF-amide, rat GHRF, human GHRF, peptide histidine isoleucine 27, rat pancreatic polypeptide, motilin, peptide YY, substance P, neuropeptide Y, and CGRP. The histochemical antibody for VIP is generated in a rabbit against porcine VIP conjugated to bovine thyroglobulin with carbodiimide. The antibody is provided as 100 μL of lyophilized whole serum, and 0.09 % sodium azide. |
Purification | Whole Serum |
Immunogen | Vasoactive Intestinal Peptide |
Isotype | IgG |
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Antigen | |
Alternative Name | VIP (Vip Antibody Abstract) |
Background |
Other Names: Vasoactive intestinal polypeptide,VIP peptides |
Gene ID | 7432 |
Pathways | Hormone Activity, cAMP Metabolic Process |
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Restrictions | For Research Use only |
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Format | Liquid |
Buffer | Contains ≤ 0.09 % sodium azide |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C/-20 °C |
Storage Comment | After reconstitution, use immediately or refrigerate at 2 - 8 °C up to 2 days. For long-term storage aliquot antibody and freeze at -15 °C or lower. Avoid repeated freeze/thaw cycles. |
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Product cited in: |
Yamagata, Ogiwara, Mazaki, Yanagawa, Yamakawa: "Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2." in: Biochemical and biophysical research communications, Vol. 491, pp. 1070-1076, 2017 Strobel, Sullivan, Stratton, Sah: "Calcium signalling in medial intercalated cell dendrites and spines." in: The Journal of physiology, Vol. 595, pp. 5653-5669, 2017 Tuncdemir, Fishell, Batista-Brito: "miRNAs are Essential for the Survival and Maturation of Cortical Interneurons." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 25, Issue 7, pp. 1842-57, 2015 Ma, Yao, Fu, Yu: "Development of layer 1 neurons in the mouse neocortex." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 24, Issue 10, pp. 2604-18, 2014 Pohlkamp, Dávid, Cauli, Gallopin, Bouché, Karagiannis, May, Herz, Frotscher, Staiger, Bock: "Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 24, Issue 11, pp. 3046-58, 2014 Hasan, Smith: "Decreased adrenoceptor stimulation in heart failure rats reduces NGF expression by cardiac parasympathetic neurons." in: Autonomic neuroscience : basic & clinical, Vol. 181, pp. 13-20, 2014 Iijima, Iijima, Witte, Scheiffele: "Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1." in: The Journal of cell biology, Vol. 204, Issue 3, pp. 331-42, 2014 Robertson, Croll, Smith: "The structure of the caudal wall of the zebrafish (Danio rerio) swim bladder: evidence of localized lamellar body secretion and a proximate neural plexus." in: Journal of morphology, Vol. 275, Issue 8, pp. 933-48, 2014 Tyan, Chamberland, Magnin, Camiré, Francavilla, David, Deisseroth, Topolnik: "Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 13, pp. 4534-47, 2014 Perrenoud, Rossier, Geoffroy, Vitalis, Gallopin: "Diversity of GABAergic interneurons in layer VIa and VIb of mouse barrel cortex." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 23, Issue 2, pp. 423-41, 2013 Dvorackova, Macak, Brzula, Tomanova, Dokulil: "Primary neuroendocrine carcinoma of the kidney." in: Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, Vol. 157, Issue 3, pp. 257-60, 2013 Montgomery, Whitt, Wright, Lai, Meredith: "Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior." in: American journal of physiology. Cell physiology, Vol. 304, Issue 4, pp. C299-311, 2013 Schuster, Dykstra, Riedl, Kitto, Honda, McIvor, Fairbanks, Vulchanova: "Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 25, Issue 2, pp. e89-100, 2013 Cox, Racca: "Differential dendritic targeting of AMPA receptor subunit mRNAs in adult rat hippocampal principal neurons and interneurons." in: The Journal of comparative neurology, Vol. 521, Issue 9, pp. 1954-2007, 2013 Hioki, Okamoto, Konno, Kameda, Sohn, Kuramoto, Fujiyama, Kaneko: "Cell type-specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 2, pp. 544-55, 2013 Donadio, Incensi, Cortelli, Giannoccaro, Jaber, Baruzzi, Liguori: "Skin sympathetic fiber α-synuclein deposits: a potential biomarker for pure autonomic failure." in: Neurology, Vol. 80, Issue 8, pp. 725-32, 2013 Dvořáčková, Mačák, Buzrla: "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: case report and review of literature." in: Ceskoslovensk�� patologie, Vol. 49, Issue 2, pp. 99-102, 2013 Kudo, Tahara, Gamble, McMahon, Block, Colwell: "Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus." in: Journal of neurophysiology, Vol. 110, Issue 5, pp. 1097-106, 2013 Uyttebroek, Shepherd, Hubens, Timmermans, Van Nassauw: "Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells." in: Cell and tissue research, Vol. 354, Issue 2, pp. 355-70, 2013 Komitova, Xenos, Salmaso, Tran, Brand, Schwartz, Ment, Vaccarino: "Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 33, pp. 13375-87, 2013 |
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