|Antigen||Vasoactive Intestinal Peptide (Vip) Antibodies|
|Reactivity||Cow (Bovine), Dog (Canine), Horse (Equine), Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine) Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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|Specificity||The antibody recognizes VIP.|
Species reactivity (expected):Mouse, Rat, Bovine, Canine (Dog), Horse, Pig, Rhesus Monkey and Sheep.
Species reactivity (tested):Human.
|Purification||Affinity Chromatography on Protein G.|
|Immunogen||Synthetic peptide corresponding to part of the native molecule conjugated to Keyhole Limpet Heamocyanin|
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|Alternative Name||VIP Peptides (Vip Antibody Abstract)|
|Background||Vasoactive Intestinal Peptide (VIP), a 28 amino acid peptide originally isolated from porcine duodenum, is present not only in gastrointestinal tissues but also in neural tissues, possibly as a neurotransmitter, and exhibits a wide variety of biological actions. It belongs to the glucagon family, and in the duodenum is known to stimulate myocardial contractility, cause vasodilation, increase glycogenolysis, lower arterial blood pressure and relax the smooth muscle of trachea, stomach and gall bladder. Ectopic endocrine tumors secreting VIP (VIPomas) give rise to raised plasma levels of VIP and are associated with watery diarrhea, hypokalemia and achlorhydria syndrome.Synonyms: VIP, Vasoactive intestinal peptide|
|Pathways||Hormone Activity, cAMP Metabolic Process|
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Immunohistology on Paraffin Embedded Tissues: positive staining is seen in the ganglioncells in both the superficial and deep plexus of the wall of the small bowel.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||PBS containing 0.09 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|