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results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC.
These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling.
our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation
MR-proADM but not copeptin (show AVP Proteins) was significantly associated with prognosis of COPD (show ARCN1 Proteins) exacerbations at 30 days.
Findings indicate the importance of cancer-associated fibroblasts (CAFs (show TBX1 Proteins))-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis.
Mouse and human heart valves expressed mRNAs for the CRL (show IL31RA Proteins) ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL (show IL31RA Proteins) and receptor-activity-modifying proteins 1-3.
SHH (show SHH Proteins) acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .
Our findings showed that adrenomedullin expression increased in progression from benign endometrium to endometrial intraepithelial neoplasia and type-1 adenocarcinoma
The levels of IL-8 (show IL8 Proteins), IL-12 (show IL12A Proteins), and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF (show SCN5A Proteins).
Evidence show that ADM could affect the growth and differentiation of leukemia cells by modulating RAMPs/CRLR (show CALCRL Proteins) expression, PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) cascade and the ERK/MAPK (show MAPK1 Proteins) signaling pathway.
The AM-RAMP2 (show RAMP2 Proteins) system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (show ADM2 Proteins)) and calcitonin gene-related peptide (CGRP (show CALCA Proteins)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.
vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin
It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.
Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.
These results indicate the AM-RAMP2 (show RAMP2 Proteins) system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase (show NOX1 Proteins) probably by suppressing the local renin (show REN Proteins)-angiotensin system.
Hypoxia upregulates expression of the Notch ligand Dll4 (show DLL4 Proteins) and increases Notch (show NOTCH1 Proteins) signaling in a process requiring the vasoactive hormone adrenomedullin.
Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (show CALCRL Proteins), RAMP2 (show RAMP2 Proteins) and RAMP3 (show RAMP3 Proteins) were detected in cotyledonary villous and caruncular epithelial cells.
The present study thus showed that neither leptin (show LEP Proteins) nor resistin (show RETN Proteins) affects the expression of endothelin-1 (show EDN1 Proteins) or adrenomedullin in bovine brain microvascular endothelial cells.
Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (show CALCRL Proteins) (calcitonin gene-related peptide (show CALCA Proteins) receptor; not adrenomedullin receptor (show GPR182 Proteins)).
adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK (show MAPK1 Proteins)-dependent manner
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.