Browse our anti-Diacylglycerol O-Acyltransferase 1 (DGAT1) Antibodies

Human Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. Study identified a large cohort of patients with congenital diarrheal disorders with mutations in DGAT1 that reduced expression of its product; dermal fibroblasts and intestinal organoids derived from these patients had altered lipid metabolism and were susceptible to lipid-induced cell death. Expression of full-length wildtype DGAT1 or DGAT2 restored normal lipid metabolism in these cells.

2. our findings indicate that inhibition of both DGAT1 and ABHD5 using siRNA leads to reduction in prostate cancer cell growth.

3. data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes.

4. DGAT1 mutations result in a spectrum of diseases

5. A novel homozygous missense variant was identified in a family with protein losing enteropathy. A splice site mutation in intron 8 was identified in a second family with PLE. These cases of DGAT1 deficiency extend the molecular and phenotypic spectrum of PLE.

6. DGAT1 expression is down-regulated in viral hepatitis-related cirrhosis.

7. Data indicate no clinically relevant pharmacokinetic interaction between DGAT-1 inhibitor pradigastat and rosuvastatin.

8. the apparent lack of therapeutic window owing to GI side effects of AZD7687, particularly diarrhoea, makes the utility of DGAT1 inhibition as a novel treatment for diabetes and obesity questionable.

9. Downregulation of CLDN1 was associated with altered fatty acid homeostasis in the absence of DGAT1.

10. MGAT2 functions as a dimeric or tetrameric protein and selectively heterodimerizes with DGAT1 in mammalian cells

11. The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described.

12. adipose overexpression of Dgat1 gene in transgenic mice leads to diet-inducible insulin resistance.

13. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core

14. results identify DGAT1 loss-of-function mutations as a rare cause of congenital diarrheal disorders

15. describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1

16. a comprehensive evaluation of a small molecule inhibitor for DGAT1 and suggests that pharmacological inhibition of DGAT1 holds promise in treating diverse metabolic disorders.

17. DGAT1 belongs to the family of oligomeric membrane proteins that adopt a dual membrane topology.

18. human small intestinal DGAT, which is mainly encoded by DGAT1, utilizes 1,2-DAG as the substrate to form TAG

19. The triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) is identified as a key host factor for hepatitis C virus infection.

20. Identify DGAT1 as an important protein that participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins.

Mouse (Murine) Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes.

2. The endoplasmic reticulum-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated fatty acids into new, clustered lipid droplets that are in close proximity to mitochondria and are lipolytically degraded.

3. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs.

4. DGAT1 does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes...in b3-agonist activated brown adipocytes, DGAT2 specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation.

5. these results support a model where Dgat1 and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes.

6. Study provides evidence that although DGAT1 in the hematopoietic compartment does not impact the overall lipid content of atherosclerotic plaques, it exerts reciprocal effects on inflammation and fibrosis, two processes that control plaque vulnerability.

7. Our findings provide insight into a novel role of DGAT1 and identify a pathway by which intestinal DGAT1 deficiency affects whole-body cholesterol homeostasis in mice

8. g. This study implied a function role of DGAT1 in the synthesis of TAG, insulin resistance, and intramuscular fat deposition.

9. Total retinyl-ester synthase activity was reduced in both dgat1(-/-) retina and retinal pigment epithelium.

10. F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression

11. loss of DGAT1 reproduces the lipid abnormalities seen in severe human heart failure.

12. TNFalpha mediates saturated fatty acid-induced osteoclastogenesis that can be prevented by DGAT activation or supplementation with OA.

13. Compared with wild-type mice, triglyceride and DGAT1 content were approximately fourfold and 50% increased in posterior tibial muscle of the transgenic mice, respectively, while a little increase in cardiac muscle.

14. Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.

15. Intestinal DGAT1 inhibition or deficiency acutely delayed gastric emptying and inhibited chylomicron secretion; however, the latter occurred when gastric emptying was normal or when lipid was administered directly into the small intestine.

16. analysis ofsubstrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases

17. Deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.

18. Lack of DGAT1 is atheroprotective, implicating an additional application of DGAT1 inhibitors with regard to maintaining cholesterol homeostasis and attenuating atherosclerosis.

19. core first requires DGAT1 to gain access to LDs, and then LD-localized core interferes with triglyceride turnover, thus stabilizing lipid droplets and leading to steatosis

20. a comprehensive evaluation of a small molecule inhibitor for DGAT1 and suggests that pharmacological inhibition of DGAT1 holds promise in treating diverse metabolic disorders.

Cow (Bovine) Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. the effects of dietary linseed oil, DGAT1, and the interaction between dietary linseed oil and DGAT1 on CH4 and H2 emission, energy and N metabolism, lactation performance, ruminal fermentation, and rumen bacterial and archaeal composition of dairy cows

2. Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively. The DGAT1 GC/GC allele was associated with lower milk fat and protein content, lower saturated fatty acid levels, and higher polyunsaturated FA

3. study showed that the DGAT1 K232A polymorphism has major effects on FA and mineral composition of bovine milk; effects are relevant in relation to cow health, human health, and functional properties of milk fat and milk protein

4. Association of a novel mutation in DGAT1 that may be responsible for unsaturated milk fat in cattle.

5. An effect of DGAT1 identified on subcutaneous fat thickness.

6. Russian and Kazakh populations of the Kazakh white-headed breed were characterized by a high content of the AA genotype of RORC (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975)

7. Studied the occurrence of the DGAT1 p.Lys232Ala polymorphism in Romanian Holstein cattle and Romanian Buffalo breeds and further investigated its possible influence on fat percentage and fatty acid profiles.

8. Novel SNPs and INDEL polymorphism in DGAT1 are associated with milk production and protein and fat milk composition.

9. Single nucleotide polymorphisms in the DGAT1 gene significantly effected fat distribution in Chinese commercial cattle.

10. effects of K232A polymorphism on milk fat composition in winter and summer

11. results indicated that knockdown of DGAT1 expression significantly reduced triglyceride content in bovine mammary epithelial cells

12. The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

13. pleiotropic effects of polymorphism Ala to Lys amino acid substitution at position 232 in mammary gland tissue

14. The impact of different alleles of DGAT1 and leptin on milk production in Giorlando cattle is reported.

15. Genotype KK has the greatest effect on all milk composition content traits, while genotype AA has the greatest effect on yield traits. It can be concluded that the DGAT1 gene can be used as a gene marker for assisted selection in milk composition traits.

16. No differential allelic expression was observed for the DGAT1 genes in bovine fetal tissues.

17. The present study investigated putative interaction effects between the DGAT1 K232A mutation and the polygenic term (i.e., all genes except DGAT1) for 5 milk production traits in the German Holstein dairy cattle population.

18. The K232A substitution of the DGAT1 gene could be used as a golden standard in comparisons of the effect on milk productivity for the total gene set.

19. The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested.

20. Effects of the DGAT1 p.Lys232Ala on milk, fat and protein yield, as well as fat and protein percentage in the milk of 1222 Holstein cows showed DGAT1 allele that encode lysine at position 232 was associated with increased 305-day milk fat yield.

Arabidopsis thaliana Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. DGAT1 expression is regulated by MYB96 in the Arabidopsis seeds.

2. The constructed promoter was ligated upstream of the TAG1 gene encoding diacylglycerol acyltransferase 1 and introduced into Arabidopsis. Seeds from transgenic plants carrying AtTAG1 under the control of the chimeric promoter showed increased oil content (up by 1873%) compared with wild-type seeds.

3. This study identifies the first two regulatory genes, WRI1 and DGAT1, that control the synthesis of all tocochromanol forms in seeds, and shows the existence of a metabolic trade-off between lipid and tocochromanol metabolisms.

4. The results suggest that dedifferentiation is associated with Tag1 activation and that CMT3 rather than DDM1 plays a central role in restraining Tag1 activation via inducing gene body DNA methylation.

5. ABI4 and ABI5 synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress.

6. Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.

7. ABI4 is essential for the activation of DGAT1 in Arabidopsis seedlings during nitrogen deficiency.

8. PDAT1 and DGAT1 have overlapping functions for triacylglycerol synthesis in both seed and pollen, and that the absence of their function leads not only to a reduction in TAG, but also to critical defects in normal pollen and embryo development.