Browse our anti-Diacylglycerol O-Acyltransferase 1 (DGAT1) Antibodies

Human Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. Study identified a large cohort of patients with congenital diarrheal disorders with mutations in DGAT1 that reduced expression of its product; dermal fibroblasts and intestinal organoids derived from these patients had altered lipid metabolism and were susceptible to lipid-induced cell death. Expression of full-length wildtype DGAT1 or DGAT2 (show DGAT2 Antibodies) restored normal lipid metabolism in these cells.

2. our findings indicate that inhibition of both DGAT1 and ABHD5 (show ABHD5 Antibodies) using siRNA leads to reduction in prostate cancer cell growth.

3. data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes.

4. DGAT1 mutations result in a spectrum of diseases

5. A novel homozygous missense variant was identified in a family with protein losing enteropathy. A splice site mutation in intron 8 was identified in a second family with PLE. These cases of DGAT1 deficiency extend the molecular and phenotypic spectrum of PLE.

6. DGAT1 expression is down-regulated in viral hepatitis-related cirrhosis.

7. Data indicate no clinically relevant pharmacokinetic interaction between DGAT-1 inhibitor pradigastat and rosuvastatin.

8. the apparent lack of therapeutic window owing to GI side effects of AZD7687, particularly diarrhoea, makes the utility of DGAT1 inhibition as a novel treatment for diabetes and obesity questionable.

9. Downregulation of CLDN1 (show CLDN1 Antibodies) was associated with altered fatty acid homeostasis in the absence of DGAT1.

10. MGAT2 (show MGAT2 Antibodies) functions as a dimeric or tetrameric protein and selectively heterodimerizes with DGAT1 in mammalian cells

Mouse (Murine) Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes.

2. The endoplasmic reticulum-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated fatty acids into new, clustered lipid droplets that are in close proximity to mitochondria and are lipolytically degraded.

3. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase (show LIPG Antibodies) inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL (show PNPLA2 Antibodies)-deficient mouse Hepatic stellate cell (HSC (show FUT1 Antibodies)). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin (show ACTG2 Antibodies), in rat HSCs, but not in mouse HSCs.

4. DGAT1 does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 (show DGAT2 Antibodies) also contributes...in b3-agonist activated brown adipocytes, DGAT2 (show DGAT2 Antibodies) specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation.

5. these results support a model where Dgat1 and Dgat2 (show DGAT2 Antibodies) function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes.

6. Study provides evidence that although DGAT1 in the hematopoietic compartment does not impact the overall lipid content of atherosclerotic plaques, it exerts reciprocal effects on inflammation and fibrosis, two processes that control plaque vulnerability.

7. Our findings provide insight into a novel role of DGAT1 and identify a pathway by which intestinal DGAT1 deficiency affects whole-body cholesterol homeostasis in mice

8. g. This study implied a function role of DGAT1 in the synthesis of TAG, insulin (show INS Antibodies) resistance, and intramuscular fat deposition.

9. Total retinyl-ester synthase activity was reduced in both dgat1(-/-) retina and retinal pigment epithelium.

10. F3MB(PANDER (show FAM3B Antibodies)) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression

Cow (Bovine) Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. the effects of dietary linseed oil, DGAT1, and the interaction between dietary linseed oil and DGAT1 on CH4 (show COPS4 Antibodies) and H2 emission, energy and N metabolism, lactation performance, ruminal fermentation, and rumen bacterial and archaeal composition of dairy cows

2. Here, the association between DGAT1 K232A, SCD1 (show SCD Antibodies) A293V, and LEPR (show LEPR Antibodies) T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1 (show SCD Antibodies), and LEPR (show LEPR Antibodies) polymorphisms were GC/GC (show GC Antibodies), C, and C, respectively. The DGAT1 GC/GC (show GC Antibodies) allele was associated with lower milk fat and protein content, lower saturated fatty acid levels, and higher polyunsaturated FA

3. study showed that the DGAT1 K232A polymorphism has major effects on FA and mineral composition of bovine milk; effects are relevant in relation to cow health, human health, and functional properties of milk fat and milk protein (show CSN2 Antibodies)

4. Association of a novel mutation in DGAT1 that may be responsible for unsaturated milk fat in cattle.

5. An effect of DGAT1 identified on subcutaneous fat thickness.

6. Russian and Kazakh populations of the Kazakh white-headed breed were characterized by a high content of the AA genotype of RORC (show RORC Antibodies) (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975)

7. Studied the occurrence of the DGAT1 p.Lys232Ala polymorphism in Romanian Holstein cattle and Romanian Buffalo breeds and further investigated its possible influence on fat percentage and fatty acid profiles.

8. Novel SNPs and INDEL polymorphism in DGAT1 are associated with milk production and protein and fat milk composition.

9. Single nucleotide polymorphisms in the DGAT1 gene significantly effected fat distribution in Chinese commercial cattle.

10. results indicated that knockdown of DGAT1 expression significantly reduced triglyceride content in bovine mammary epithelial cells

Arabidopsis thaliana Diacylglycerol O-Acyltransferase 1 (DGAT1) interaction partners

1. This study identifies the first two regulatory genes, WRI1 and DGAT1, that control the synthesis of all tocochromanol forms in seeds, and shows the existence of a metabolic trade-off between lipid and tocochromanol metabolisms.

2. The results suggest that dedifferentiation is associated with Tag1 activation and that CMT3 rather than DDM1 plays a central role in restraining Tag1 activation via inducing gene body DNA methylation (show HELLS Antibodies).

3. ABI4 and ABI5 (show ABI5 Antibodies) synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress.

4. Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC (show PCSK7 Antibodies) by LPCAT2 (show LPCAT2 Antibodies).

5. ABI4 is essential for the activation of DGAT1 in Arabidopsis seedlings during nitrogen deficiency.

6. PDAT1 and DGAT1 have overlapping functions for triacylglycerol synthesis in both seed and pollen, and that the absence of their function leads not only to a reduction in TAG, but also to critical defects in normal pollen and embryo development.