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The effects of dietary energy on the metabolism of ghrelin (show GHRL Proteins), leptin (show LEP Proteins) and growth hormone secretagogue receptor in blood and tissues of steers are reported.
The coding regions of GHSR and SLC2A2 (show SLC2A2 Proteins) were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2 (show SLC2A2 Proteins), and three were detected in GHSR.
provided conclusive evidence that the 19-TG allele of the 5'UTR microsatellite of the bovine GHSR1a gene affects growth and carcass traits in Japanese Black cattle
We evaluated the haplotype variety and characterized the microsatellite ((TG)(n) , 5'-UTR) and nucleotide polymorphisms of the bovine GHSR1a gene.
Ghrelin (show GHRL Proteins) concentrations significantly decreased from pregnancy to 6 weeks postpartum and this change differed based on pregnancy depression status. Finally, ghrelin (show GHRL Proteins) levels were lower in women who breastfed compared with women who were bottle-feeding.
it showed that the antinociception of ghrelin (show GHRL Proteins) was correlated with the GHS-R1alpha and d-opioid receptors. Finally, the antinociception induced by deltorphin II wasn't blocked by the co-injection (i.c.v.) of [D-Lys (show LYZ Proteins)(3)]-GHRP-6, indicating that the GHS-R1a isn't on the backward position of delta opioid receptor.
our results showed for the first time that the downregulation of GHSR1a by shRNA technology inhibits the growth of colorectal cancer cell line and xenograft tumor through upregulation of PTEN at transcription as well as translation levels.
GHSR mutations are associated with Obesity.
Results indicate that neuronal GHS-R is a crucial regulator of energy metabolism and a key mediator of DIO. Neuronal Ghsr deletion protects against DIO by regulating energy expenditure, not by energy intake. These novel findings suggest that suppressing central ghrelin (show GHRL Proteins) signaling may serve as a unique antiobesity strategy.
Results suggest that the minor allele of the rs2948694 in the GHSR gene was associated with increased smoking possibly reflects an association with alcohol use disorder and nicotine dependence.
GHS-R1b (show HOXB7 Proteins) not only determines the efficacy of ghrelin (show GHRL Proteins)-induced GHS-R1a-mediated signaling but also determines the ability of GHS-R1a to form oligomeric complexes with other receptors.
The data indicates that GHSR hypermethylation is a pan-cancer marker regardless of the tissue from which the tumor originates.
the single nucleotide polymorphism of GHSR might be weaker association with cancer risk, especially with breast cancer risk
Data (including data from knockout mice) suggest ghrelin (show GHRL Proteins) produced in pancreatic islets regulates insulin (show INS Proteins) secretion and thereby regulates blood glucose; ghrelin (show GHRL Proteins) signaling via growth hormone secretagogue-receptor appears to be involved. [REVIEW]
GHSR expression in primary neurons is not only modulated in a time-dependent manner but also that there might be a selective regional distribution which might yield to functional modulatory effects of ghrelin (show GHRL Proteins) in the brain areas.
Fasting upregulates Fpn1 (show SLC40A1 Proteins) expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL Proteins)/GHSR1a/MAPK (show MAPK1 Proteins) signaling pathway.
our results suggest that AgRP (show AGRP Proteins) neurons are key site for GHS-R mediated thermogenesis, and demonstrate that GHS-R in AgRP (show AGRP Proteins) neurons plays crucial roles in governing energy utilization and pathogenesis of DIO.
Growth hormone secretagogue receptor (GHSR) deficiency suppresses smooth muscle cell (SMCs) numbers in in the neointima.
Studies demonstrate that ghrelin (show GHRL Proteins) signaling has an important role in macrophage polarization and adipose tissue inflammation during aging.
Study demonstrated that NMDAR (show GRIN1 Proteins) functions are regulated by ghrelin (show GHRL Proteins) in a GHSR1a-dependent manner: NMDAR (show GRIN1 Proteins)-mediated synaptic currents are increased as a result of GluN1 (show GRIN1 Proteins) subunit phosphorylation in the hippocampal pyramidal neurons and synapses
Ghsr mediates the beneficial effects of Caloric restriction on enhancing adult hippocampal neurogenesis and memory.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Proteins)) and neuropeptide Y (Npy (show NPY Proteins)) gene expression similarly in Ghrelin (show GHRL Proteins)+/+, Ghrelin (show GHRL Proteins)-/-, ghrelin receptor Ghsr+/+, and Ghsr-/- mice.
The expression of ghrelin (show GHRL Proteins) and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin (show GHRL Proteins) analogs on cerebrovascular function are reproted.[GHSR1a]
Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Proteins) channels by Gi/o or Gq protein pathways depending on its mode of activation.
GHSR-1a is present in prepubertal pig ovary; no influence of GH on GHSR-1a expression is found.
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein\; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin\; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
, growth hormone secretagogue receptor type 1
, growth hormone secretagogue receptor
, ghrelin/growth hormone secretagogue receptor
, growth hormone secretagogue receptor type 1A
, growth hormone secretagogue receptor, type 1A
, growth hormone secretagogue receptor type 1-like
, GH-releasing peptide receptor
, G-protein coupled receptor
, growth hormone secretagogue receptor type 1b