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Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
Show all 5 Pubmed References
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988
Show all 5 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
Show all 4 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN620832
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN804234
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN935537
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747
Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
the single nucleotide polymorphism rs1800797 of IL6 may be a susceptibility gene for major depressive disorder
the association between TLR3 (show TLR3 Proteins), TLR4 (show TLR4 Proteins) variants and nine IL-6 polymorphisms, and response to anti-viral treatment during hepatitis C infection.
this study shows age-related increases in serum and PBMC IL-6 in healthy nonobese subjects
hese findings suggest that variations in IL6, CXCL8 (show IL8 Proteins), and TNF (show TNF Proteins) are associated with the development and maintenance of mild persistent breast pain.
theses results suggest that IL-6 genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation
serum concentrations of IL-6 and IL-10 (show IL10 Proteins) but not TNFa (show TNF Proteins) in patients with internal carotid artery stenosis allow to predict the progression of the degree of stenosis and the unfavorable change of atherosclerotic plaque morphology
Approximately half of the knee osteoarthritis patients were found to be in the depressive state, and their serum IL-6 levels to be associated with the depressive state, irrespective of osteoarthritis severity.
increased levels of IL-6 are associated with factors of worse prognosis in ovarian cancer
IL-6 upregulation in the adventitia was characterized by activated immune reactions in IgG4-abdominal aortic aneurysm patients. IL-6 synthesis, through contributions of mesenchymal cells and macrophages in the adventitia, is strongly involved in IgG4-AA pathogenesis or progression, or both.
IL-11 (show IL11 Proteins), an IL-6 Family Cytokine, promotes Non-Small Cell Lung Cancer cell proliferation in vitro and tumorigenesis in vivo.
IL 6 and TGF beta (show TGFB1 Proteins) perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.
EMMPRIN inhibited bFGF (show FGF2 Proteins)-induced IL-6 secretion by reducing the p65 (show NFkBP65 Proteins) subunit phosphorylation, it might be concluded that bFGF (show FGF2 Proteins) and EMMPRIN crosstalk in their respective signaling pathways.
pathologic levels of IL-6 in the periphery may play a role in the development of seizures when viral replication within the brain is limited following infection with a variant of Theiler's murine encephalomyelitis virus that does not replicate within the parenchyma of the brain.
IL-33 (show IL33 Proteins) may induce Th17 cell responses via IL-1beta (show IL1B Proteins) and IL-6 derived from IL-33 (show IL33 Proteins)-matured dendritic cells.
TIARP (show STEAP4 Proteins) independently down-regulated CXCL2 (show CXCL2 Proteins) and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine (show CCL1 Proteins) receptors (CXCR1 (show CXCR1 Proteins) and CXCR2 (show CXCR2 Proteins)) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints.
ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta (show IL1B Proteins) and IL-6 production through NF-kappaB (show NFKB1 Proteins) and the Shh (show SHH Proteins) signaling pathway.
these findings revealed a novel and unexpected role of IL-6 in ameliorating acute liver injury via regulating inflammatory responses in hepatic macrophages
increased circulating levels of IL-6 perturb the redox signaling cascade, even prior to the necrotic stage, leading to severe features and progressive nature of muscular dystrophy.
LPS (show TLR4 Proteins) increased mRNA and protein expressions of IL-6 and RANKL (show TNFSF11 Proteins) on day 14
The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via alpha7AChRs upstream of Stat-3 (show STAT3 Proteins) and -5 pathways and is associated with myonuclear accretion, possibly via MyoD (show MYOD1 Proteins) and Pax7 (show PAX7 Proteins) expression.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Proteins)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).
LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.
STA3 (show ARHGEF3 Proteins) facilitates TLR4 (show TLR4 Proteins)-dependent IL-6 and IL-8 (show IL8 Proteins) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)