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Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
Show all 5 Pubmed References
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988
Show all 5 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
Show all 4 Pubmed References
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN620832
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN804234
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN935537
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747
Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
Serum IL-6 and fibrinogen levels seem to be two promising inflammatory markers in the discrimination of infected diabetic foot ulcer.
higher levels of IL-6 and VEGF-A (show VEGFA Proteins) were significantly associated with shorter progression free survival in epithelial ovarian cancer
evamisole inhibited CD138 (show SDC1 Proteins) expression and affected the levels of IL-6 in a dose-dependent manner. The results of the present study add new dimension to levamisole's mode of action as inhibitor of CD138 (show SDC1 Proteins) and IL-6 and as an antiapoptotic agent.
Suppression of IL-6 remarkably promoted antitumor effect of gemcitabine.
the polymorphism -174G>C in the IL-6 promoter region was associated with a significantly increased risk of obesity (Meta-Analysis)
Serum IL-6 levels were significantly lower in children with febrile seizures as compared to febrile controls.
Suggest IL-6 can induce hepcidin (show HAMP Proteins) in systemic lupus erythematosus flares.
The levels of salivary IL-6 and IL-17 (show IL17A Proteins) were increased significantly in calculus associated Chronic periodontitis patients.
Interleukin-6 was upregulated in blood of gastric cancer patients and study results indicate that Interleukin-6 promotes tumor growth and metastasis in gastric cancer
interleukin 6 (IL-6) was secreted by bystander unirradiated cells (UICs), particularly the UICs with pre-induced autophagy.
Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR (show FCER2 Proteins)) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells.
TRYP improves the health condition of mice with DSS (show PMP22 Proteins) induced colitis by regulating the TNF-&alpha (show TNF Proteins);/NF-κBp65 and IL-6/STAT3 (show STAT3 Proteins) signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3 (show STAT3 Proteins).
Our results demonstrate that IL-6 activation in placenta is required for relaying inflammatory signals to the fetal brain and impacting behaviors and neuropathologies relevant to neurodevelopmental disease.
An IL-6 infusion model can initiate macrophage accumulation as well as aortic dilation, and under conditions of elevated tension, this proinflammatory cytokine can be produced by aortic vascular smooth muscle cells.
miR (show MLXIP Proteins)-155 seems to target Est-1 (show AP1S2 Proteins) and induces ulcerative colitis via the IL-23 (show IL23A Proteins)/17/6-mediated Th17 pathway.
IL-6 and aging are involved in regulation of PPARalpha and PGC-1alpha expression and may influence the mitochondrial function.
CGRPinduced IL6 mRNA expression was mediated by mmu_circRNA_007893.
The results of this study indicated that persistently increased levels of IL-6 can lead to alterations in mTOR (show FRAP1 Proteins) regulation of L-LTP (show SCP2 Proteins).
These data demonstrate that the Pb18 strain of Paracoccidioides brasiliensis is able to activate the transcription of Notch1 (show NOTCH1 Proteins) receptor in J774 macrophages. Activation of this receptor with also activation of TLR 4 (show TLR4 Proteins) (via LPS (show TLR4 Proteins)) induces IL-6 production, which favors the pathogenesis.
IRF-1 (show IRF1 Proteins) may be at the nexus of the interplay between IFN-gamma (show IFNG Proteins) and IL-6 in exacerbating a xenobiotic-induced inflammatory response, regulation of interferon (show IFNA Proteins) responsive genes and autoimmunity
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Proteins)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).
LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.
STA3 (show ARHGEF3 Proteins) facilitates TLR4 (show TLR4 Proteins)-dependent IL-6 and IL-8 (show IL8 Proteins) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)