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AICAR Inhibitor

CC, Func Cell-permeable 2627-69-2 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
Pubmed (2)
Catalog No. ABIN412289
$130.00
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50 mg ABIN412289
50 mg ABIN412289
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  • Application
    Cell Culture (CC), Functional Studies (Func)
    Purpose
    An AMPK activator
    Characteristics
    A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
    Purity
    ≥ 98 % by HPLC
    Chemical Name
    5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
    Formula
    C₉H₁₄N₄O₅
    Permeability
    Cell-permeable
  • Restrictions
    For Research Use only
  • Format
    Powder
    Handling Advice
    Protect from air and moisture
    Storage
    -20 °C
    Expiry Date
    24 months
  • Adamo, Zhang, García-Cardeña: "AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts." in: BMC pharmacology, Vol. 9, pp. 2, 2009 (PubMed).

    Hayashi, Hirshman, Kurth, Winder, Goodyear: "Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport." in: Diabetes, Vol. 47, Issue 8, pp. 1369-73, 1998 (PubMed).

  • Molecular Weight
    258.23 g/mol
    CAS-No
    2627-69-2
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