AICAR

Details for Product No. ABIN412289, Supplier: Log in to see
Application
Cell Culture (CC), Functional Studies (Func)
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Purpose An AMPK activator
Characteristics A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
Purity ≥ 98 % by HPLC
Chemical Name 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
Formula C₉H₁₄N₄O₅
Permeability Cell-permeable
Molecular Weight 258.23 g/mol
CAS-No 2627-69-2
Restrictions For Research Use only
Format Powder
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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Product cited in: Adamo, Zhang, García-Cardeña: "AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts." in: BMC pharmacology, Vol. 9, pp. 2, 2009 (PubMed).

Hayashi, Hirshman, Kurth, Winder, Goodyear: "Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport." in: Diabetes, Vol. 47, Issue 8, pp. 1369-73, 1998 (PubMed).