Caspase-9 Inhibitor Z-LEHD-FMK Inhibitor
Func, CC, BR, InhA Cell-permeable Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
Catalog No. ABIN412392
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- Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
- A caspase-9 inhibitor
- PubChem CID: 44135217
A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
- > 98 % by HPLC
- Chemical Name
- Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
- Application Notes
- Centrifuge the vial prior to opening. We recommend using 1000-5000X dilutions for inhibiting caspase-9 activity in cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
- For Research Use only
- 10 mM
- Handling Advice
- Protect from light and moisture
- -20 °C
- Expiry Date
- 12 months
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Song, Zhou, Kim, Shapiro, Liu, Ferran, Choi, Otterbein: "Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44327-34, 2004 (PubMed).
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Morishima, Nakanishi, Takenouchi, Shibata, Yasuhiko: "An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34287-94, 2002 (PubMed).
Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).
Chatterjee, Brite, Matsumura: "Induction of apoptosis of integrin-expressing human prostate cancer cells by cyclic Arg-Gly-Asp peptides." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 10, pp. 3006-11, 2001 (PubMed).
- Ying, Yang, Tsai, Hsieh, Huang, Bau, Hsieh: "Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway." in: Archives of toxicology, 2011 (PubMed).
- Molecular Weight
- 690.7 g/mol
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