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anti-Rat (Rattus) PIK3C2B Antibodies:
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Human Monoclonal PIK3C2B Primary Antibody for IF, WB - ABIN4948244
Norris, Pombo, Shirley, Blevins, Tablin: Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. in Journal of veterinary internal medicine 2016
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
nuclear cap binding protein subunit 2
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
, phosphoinositide-3-kinase, class 2, beta polypeptide
, PTDINS-3-kinase C2 beta
, phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide
, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
, phosphoinositide 3-kinase-C2-beta
, ptdIns-3-kinase C2 subunit beta