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comparative analysis of phd1, 2, and 3 expression in Xenopus laevis
Selective reduction of PHD1 protein using CRISPR/Cas9 technology reduced both lipid peroxidation and mitochondrial impairment, and attenuated glutamate (show GRIN1 ELISA Kits) toxicity in the cultured neurons.
Phd1 deficiency in dendritic cells significantly reduced interleukin-1beta production in response to lipopolysaccharide. Taken together, our results further support the development of selective PHD1 inhibitors for ulcerative colitis, and identify haematopoietic cells as their primary target.
PHD1 deficiency promotes hepatic steatosis and liver-specific insulin (show INS ELISA Kits) resistance but does not worsen the deleterious effects of HFD on metabolic homeostasis.
deleting Phd1-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.
These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke.
PHD1 and PHD3 (show EGLN3 ELISA Kits) deletions promote angiogenesis in ischemia-injured tissue by increasing HIF1-alpha (show HIF1A ELISA Kits) stability.
Rosiglitazone increases PHD (show PDC ELISA Kits) expression in a PPARgamma (show PPARG ELISA Kits)-dependent manner and that this leads to the commitment of anti-adipogenic proteins to the ubiquitination-proteasomal pathway and to the subsequent induction of adipocyte differentiation.
PHD-1 deficient mouse appears to be the first animal model showing neuroepithelial bodies cell hyperplasia
Alterations in the function of all 3 isoforms of prolyl-4-hydroxylase enzymes (PHD1-3) in the first 24 h following transient focal cerebral ischaemia are reported.
Data show it is feasible to reactivate hepatic erythropoietin (show EPO ELISA Kits) production using systemically delivered siRNAs targeting the EglN1 (show EGLN1 ELISA Kits), EglN2 and EglN3 (show EGLN3 ELISA Kits) prolyl hydroxylase mRNA specifically in the liver.
In advanced-stage Hodgkin's Lymphoma patients strong cytoplasmic PHD1 expression in Reed-Sternberg cells was associated with poor relapse-free survival among patients treated with involved-field radiotherapy and advanced-stage patients treated with doxorubicin, bleomycin, vinblastine and darcabazine and involved-field radiotherapy.
PHD1 is phosphorylated by CDK2 (show CDK2 ELISA Kits), CDK4 (show CDK4 ELISA Kits) and CDK6 (show CDK6 ELISA Kits) at Serine 130.
siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin (show INS ELISA Kits) secretion in pancreatic Beta cells.
EglN2 associates with the NRF1 (show NFE2L1 ELISA Kits)-PGC1alpha complex and controls mitochondrial function in breast cancer
rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD (show ARCN1 ELISA Kits) in Chinese populations of Hainan province.
Germ-line PHD1 and PHD2 (show EGLN1 ELISA Kits) mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia
study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC
Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.
PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha (show EPAS1 ELISA Kits).
PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation.
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
EGL nine homolog 2
, egl nine homolog 2
, Egl nine homolog 2
, EGL nine (C.elegans) homolog 2
, egl nine homolog 2 (C. elegans)
, egl nine homolog 2-like
, HIF-prolyl hydroxylase 1
, hypoxia-inducible factor prolyl hydroxylase 1
, immediate early response 4
, prolyl hydroxylase domain-containing protein 1
, HIF-1alpha prolyl-4-hydroxylase-1
, estrogen-induced tag 6