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Knockdown of MED30 led to reduction of the tumour parameters proliferation, migration, and invasion in the bladder cancer (BCa (show BLNK Proteins)) cell lines.
analysis of a novel transcript of MED30, termed MED30 short (MED30s) generated by alternative splicing
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID (show TBP Proteins)-associated TAF(II (show TAF5 Proteins))s.
MED30 was overexpressed in gastric cancer tissues and cell lines. Moreover, MED30 overexpression increased the proliferation, migration, and invasion of gastric cancer cells
Data show a missense mutation in Med30 causing progressive cardiomyopathy in homozygous mice that, although viable during lactation, show precipitous lethality 2-3 wk after weaning.
The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002
mediator complex subunit 30
, TRAP/Mediator complex component TRAP25
, thyroid hormone receptor associated protein 6
, mediator of RNA polymerase II transcription subunit 30
, putative mediator of RNA polymerase II transcription subunit 30
, thyroid hormone receptor-associated protein 6
, thyroid hormone receptor-associated protein complex 25 kDa component