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Low NKX2-1 expression is associated with thyroid carcinomas.
One familial cohort reported that Neuroendocrine cell hyperplasia of infancy (NEHI) is associated with a heterozygous variant of NKX2.1/TTF1. Four adult relatives with heterozygous NKX2.1 mutation and with clinical histories compatible with NEHI enrolled. Although clinical improvement occurs over time, NEHI may result in lifelong pulmonary abnormalities in some cases.
Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
The homeobox (show Lbx1 Proteins) domain-containing transcription factor NKX2.1 is highly expressed in the medial ganglionic eminence (MGE) and pre-optic area of the ventral subpallium and is essential for specifying cortical interneuron fate.
We demonstrated that the 14q13.2q21.1 deletion, which encompasses NKX2-1, but not FOXG1 (show FOXG1 Proteins) gene and HPE8 region, identifies a well defined, more benign, microdeletion syndrome
The genetic or epigenetic inactivation of NKX2-1/TTF-1 may play an essential role in the development and aberrant differentiation of non-TRU-type lung adenocarcinomas.
Findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes.
Immunohistochemical detection of thyroid transcription factor 1, Napsin A (show NAPSA Proteins), and P40 (show IL9 Proteins) fragment of TP63 (show TP63 Proteins) can be used in the subclassification of non-small cell lung carcinomas.
The rate of TTF-1-positive circulating tumor cells was strongly correlated with TNM (show ODZ1 Proteins) staging, vascular infiltration, lymphatic metastasis, and the levels of CA125 (show MUC16 Proteins), CA15.3, and HE4 (show WFDC2 Proteins) in endometrial carcinoma.
Study postulated that both TTF-1 and PAX-8 (show PAX8 Proteins) when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas.
Our findings demonstrate that NKX2-1 overexpression converts AFE to thyroid epithelium in a developmental time-sensitive manner and suggest a general methodology for manipulation of cell-fate decisions of developmental intermediates.
NKX2-1 binding at distal regulatory elements led to a repressed epigenetic state and transcriptional repression in the ventricular zone. Conversely, NKX2-1 is required to establish a permissive chromatin state and transcriptional activation in the sub-ventricular and mantle zones.
Study shows that within the NANCI-Nkx2.1 duplex, NANCI plays an essential role in regulating tissue identity by acting as a transcriptional rheostat to buffer Nkx2.1 expression. During lung development and in adult lung homeostasis, NANCI acts in cis (show CISH Proteins) to positively regulate Nkx2.1, and, in turn, Nkx2.1 directly inhibits NANCI expression.
data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action.
Identify regulatory link between Nkx2-1, miR (show MLXIP Proteins)-200c, and the transcription factors Nfib (show NFIB Proteins) and Myb (show MYB Proteins), adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.
A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors.
We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (show ESR1 Proteins), NKX2-1, and Tac1 (show TAC1 Proteins) regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.
Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes.
Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.
The Nkx2-1-mediated pathway in the DMH (show DST Proteins) and LH stimulates skeletal muscle function via the sympathetic nervous system and maintains youthful physiology, contributing to the delay in aging and life span extension.
This studt demonistrated that the expression of Nkx2.1 is restricted to the medial prominence in dogfish.
There exists cooperation between Nodal and Hedgehog (show SHH Proteins) pathways in the maintenance of the anterior-dorsal hypothalamus.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
NK-2 homolog A
, homeobox protein NK-2 homolog A
, homeobox protein Nkx-2.1
, thyroid nuclear factor 1
, thyroid transcription factor 1
, homeodomain protein NKx2.1
, NK2 homeobox 1
, thyroid-specific enhancer-binding protein
, thyroid transcription factor 1 TTF-1 NK-2
, thyroid transcription factor-1
, thyroid transcription factor 1a
, Homeobox protein Nkx-2.1
, LOW QUALITY PROTEIN: homeobox protein Nkx-2.1
, Thyroid nuclear factor 1
, Thyroid transcription factor 1