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Prostate cancer patients with low NKX3.1 expression are optimal candidates for intervention with 5alpha-reductase inhibitors as an adjunct to active surveillance.
During prostate cancer initiation, Nkx3.1 expression is frequently lost in both humans and mouse models. Data, including data from studies using cells from transgenic mice, suggest that androgens activate Nkx3.1 transcription via androgen receptor (show AR Proteins) binding to 11-kb region in both normal luminal cells and castration-resistant prostatic neoplasm cells via androgen response elements in Nkx3.1 3prime untranslated region.
study demonstrated that expression of homeobox protein NK-3 homolog A(Nkx3.1) influenced both the timing and magnitude of the DNA damage response in the mouse prostate
Nkx3.1 loss and Tmprss2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) upregulation do not cooperate to enhance prostate tumorigenesis in vivo.
Id4 regulates NKX3.1, Sox9 and PTEN.
activated canonical Wnt (show WNT2 Proteins) signals and Nkx3.1 function in a positive feedback loop to regulate prostate bud growth and luminal epithelial differentiation.
multiple NKX3.1 binding sites were found in the RAMP1 (show RAMP1 Proteins) locus in human prostate cancer cells and in the normal mouse prostate.
Deletions of Klf5 (show KLF5 Proteins) and Nkx3-1 do not have a additive effect in prostatic carcinogenesis in mouse model.
Transcriptional activation of prostate specific homeobox (show PRRX1 Proteins) gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).
Androgen-dependent transcription of the mouse Nkx3.1 gene is conferred through a noncanonical element within the intron of the gene.
NKX3.1 has potential utility as a prostate specific marker in the differential diagnostic distinction between nephrogenic adenoma and prostatic adenocarcinoma.
Low NKX3.1 expression is associated with hepatocellular carcinoma.
With deletion mutation analysis, plasmid construction, EMSA and oligonucleotide decoy technique, two Sp1 (show PSG1 Proteins)-elements which located between +29 to +43 and -60 to -46 of NKX3.1 gene were identified and proven to be functional elements.
The androgen-regulated homeodomain transcription factor NKX3.1 plays roles in early prostate development and functions as a prostate-specific tumor suppressor.
the association between the down-regulation of PTEN and NKX3.1 genes contributed to prostate tumorigenesis.
NKX3.1 and DYRK1B (show DYRK1B Proteins) were shown to interact via the DYRK1B (show DYRK1B Proteins) kinase domain. In vitro kinase assay showed that DYRK1B (show DYRK1B Proteins) phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover.
An NKX3.1 binding site polymorphism in the l-plastin (show LCP1 Proteins) promoter leads to differential gene expression in human prostate cancer
Analysis of prostate cancer tissues showed that the presence of a TMPRSS2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) rearrangement was highly correlated with lower levels of NKX3.1 expression consistent with the role of NKX3.1 as a suppressor of the pathogenic gene rearrangement.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
NK3 transcription factor related, locus 1
, NK3 homeobox 1
, Drosophila NK-3 transcription factor, locus 1
, homeobox protein NK-3 homolog A
, homeobox protein Nkx-3.1
, NK homeobox, family 3, A
, NK3 transcription factor homolog A
, NK-3 transcription factor, locus 1