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Chicken Polyclonal PARK7 Primary Antibody for ICC, IF - ABIN152611
Jin, Li, Davis, Zhu, Wang, Pan, Zhang: Identification of novel proteins associated with both alpha-synuclein and DJ-1. in Molecular & cellular proteomics : MCP 2007
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Human Polyclonal PARK7 Primary Antibody for ELISA, WB - ABIN249806
Ooe, Taira, Iguchi-Ariga, Ariga: Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. in Toxicological sciences : an official journal of the Society of Toxicology 2005
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Human Polyclonal PARK7 Primary Antibody for ICC, IF - ABIN151929
Hong, Shi, Chung, Quinn, Peskind, Galasko, Jankovic, Zabetian, Leverenz, Baird, Montine, Hancock, Hwang, Pan, Bradner, Kang, Jensen, Zhang: DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. in Brain : a journal of neurology 2010
Show all 4 Pubmed References
Human Monoclonal PARK7 Primary Antibody for ICC, IHC (fro) - ABIN335354
Bonné, Gilbert, Hatzfeld, Chen, Green, van Roy: Defining desmosomal plakophilin-3 interactions. in The Journal of cell biology 2003
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Zebrafish (Danio rerio) Polyclonal PARK7 Primary Antibody for WB - ABIN1881625
Bai, Mullett, Garver, Hinkle, Burton: Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. in Brain research 2006
Show all 2 Pubmed References
Human Polyclonal PARK7 Primary Antibody for ELISA, WB - ABIN564912
Morrison, Thompson, Williamson, Cheetham, Robinson: A simple cell based assay to measure Parkin activity. in Journal of neurochemistry 2011
Human Polyclonal PARK7 Primary Antibody for WB - ABIN524725
Donadio, Giusti, Cetani, Da Valle, Ciregia, Giannaccini, Pardi, Saponaro, Torregrossa, Basolo, Marcocci, Lucacchini: Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands. in Proteome science 2011
Cow (Bovine) Monoclonal PARK7 Primary Antibody for ICC, IF - ABIN4343700
Wang, Fang, Zhang, Li, Guan, Sun, Xie, Zhong: The positive correlation between DJ-1 and β-catenin expression shows prognostic value for patients with glioma. in Neuropathology : official journal of the Japanese Society of Neuropathology 2013
Melatonin, added together with MPTP (show PTPN2 Antibodies) or added once MPTP (show PTPN2 Antibodies) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (show PARK2 Antibodies)/PINK1 (show PINK1 Antibodies)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
In cultured neurons and forebrain samples from Dj1(-/-) animals, there was chloride damage and a profound structural remodeling of the mitochondrial respiratory chain.
DJ-1 has a role in glutamate (show GRIN1 Antibodies) uptake into astrocytes by regulating flotillin-1 (show FLOT1 Antibodies) and caveolin-1 (show CAV1 Antibodies) expression
Network analysis reveals DJ-1/LDLR (show LDLR Antibodies) as common host proteins modulating pathogenesis of neurotropic viruses.
Induction of DJ-1 may serve as a novel regulator for hepatocellular carcinoma cell proliferation and HCC (show FAM126A Antibodies) development possibly through enhanced MAPK (show MAPK1 Antibodies) signaling and inflammation.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (show NR4A2 Antibodies) activity.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal/RPE (show RPE Antibodies) degeneration in association with higher levels of oxidative stress markers. Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE (show RPE Antibodies) from oxidative damage during aging
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
DJ-1 is a powerful regulator of reactive oxygen species production as well as NHE1 (show SLC9A1 Antibodies) expression and activity in CD4 (show CD4 Antibodies)(+) T cells.
the present study highlighted the involvement of DJ1 in HGrelated EC injury and identified that DJ1 exerts a cellular protective effect in HUVECs exposed to HG induced oxidative stress via activation of the PI3K (show PIK3CA Antibodies)/AkteNOS signaling pathway.
These findings suggest that oxidation-induced ubiquitination and degradation can be a quality control mechanism of oxidized redox-sensitive proteins including Prxs and DJ-1.
study implies that DJ-1 may protect endothelial progenitor cells against Ang II (show AGT Antibodies)-induced dysfunction by activating the PPARgamma (show PPARG Antibodies)/HO-1 (show HMOX1 Antibodies).
Studied serum levels of Parkinson's disease-associated protein 7 (DJ-1) and human epididymis protein 4 (HE4 (show WFDC2 Antibodies)) in endometrial cancer (EC) patients and healthy controls. The median serum concentrations of DJ-1 and HE4 (show WFDC2 Antibodies) were found to be significantly higher in EC patients compared to controls.
Study shows the generation of oxDJ-1 in erythrocytes in early stage, unmedicated parkinson's disease (PD) patients and in non-human primates with PD symptoms. In addition, oxDJ-1 interacts with 20S proteasome (show PSMA5 Antibodies) in the erythrocytes of PD patients. The current findings suggest that oxidative stress is systemically present in PD patients and suggest that an early pathophysiological mechanism operates in PD.
Not only is protein deglycase DJ-1 (DJ-1) linked to familial Parkinson's disease (PD), but it is also associated with the pathogenic mechanisms of sporadic PD and other neurodegenerative disorders where oxidative stress is implicated [Review].
Studies indicate that protein deglycase DJ-1 (DJ-1) plays a critical role in cancer [Review]
Studies indicate that sperm protein deglycase DJ-1 (DJ-1 concentration in Asthenozoospermia is lower than that in control.
Studies indicate Cys (show DNAJC5 Antibodies)-106-oxidized protein deglycase DJ-1(oxDJ-1) levels in the brain and blood as a biomarker candidate for early-phase Parkinson's disease.
Data suggest that protein deglycase DJ-1 (DJ-1) plays multiple roles in many cell types under metabolically challenging conditions as seen in obesity, insulin (show INS Antibodies) resistance, and type 2 diabetes mellitus [Review].
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22