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DNA methylation (show HELLS Proteins) in a combination of POU4F2/PCDH17 (show PCDH17 Proteins) has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups.
The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells
Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 in urine specimens are promising diagnostic biomarkers for bladder cancer recurrence surveillance
Levels of CDK4 (show CDK4 Proteins) mRNA and protein correlate with levels of Brn-3b in breast cancer cell lines manipulated to express different levels of Brn-3b and in human breast cancer biopsies; Brn-3b can activate the CDK4 (show CDK4 Proteins) promoter
Brn-3b transcription factor contributes to proliferation of neuroblastoma (show ARHGEF16 Proteins) cells in vivo and in vitro but may also influence progression and/or invasion during tumorigenesis.
Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 (show HSPB1 Proteins) expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.
Brn-3b expression has been shown to be a prerequisite for developmental survival of most retinal ganglion cells.
first time that a Brn-3b POU family transcription factor has been shown to regulate a member of the catenin family, which provides insight into the molecular mechanisms by which Brn-3b expression may favour breast cancer progression and tumor invasion
Two different microRNAs that potentially regulate the stability of Brn-3b have been identified in neuroblastoma (show ARHGEF16 Proteins) cells.
May act to alter growth properties of breast cancer and neuroblastoma (show ARHGEF16 Proteins) cells by enhancing cyclin D1 (show CCND1 Proteins) expression in these tumor cells.
Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a (show POU4F1 Proteins) and Brn-3b in developing hearts.
Dlx1 and Dlx2 function both downstream of ATOH7 (show ATOH7 Proteins) and in parallel, but cooperative, pathways that involve regulation of Brn3b expression to determine retinal ganglion cell fate.
he present Pou4f2-GFP knock-in mouse line is a useful tool for further studies on the differentiation and regeneration of retinal ganglion cells
Strongylocentrotus purpuratus Pou4f1 (show POU4F1 Proteins)/2 and mouse Pou4f2 share conserved components of a gene network for photosensory development and they maintain their conserved intrinsic functions despite vast morphological differences in mouse and sea (show Slc25a1 Proteins) urchin photosensory structures.
Dynamic expression of Brn3b was identified in the somatosensory component of cranial nerves during different stages of development.
Pou4f2 KO mice exhibit profound hyperglycemia, increased GSK3B expression, and decreased GLUT4 (show SLC2A4 Proteins) expression. In C2C12 myocytes, Pou4f2 mRNA and protein are induced by glucose and inhibited by insulin (show INS Proteins).
Results suggest the existence of a coordinated mechanism by miR (show MLXIP Proteins)-23a and miR (show MLXIP Proteins)-374 to down regulate Brn3b and ultimately regulate the development of retinal ganglion cells from their precursors
Pou4f2 and Isl1 (show ISL1 Proteins), are sufficient to specify the retinal ganglion cell fate in ATOH7 (show ATOH7 Proteins) deficient mice
Increased Brn-3b and p53 (show TP53 Proteins) correlated with elevated expression of pro-apoptotic target genes, Bax (show BAX Proteins), Noxa (show PMAIP1 Proteins) and PUMA (show BBC3 Proteins), whereas cleaved caspase-3 (show CASP3 Proteins) confirmed the presence of apoptotic cells within this region of the injured heart.
Study demonstrates a sequential expression order of NEUROD1 (show NEUROD1 Proteins)>ISL1 (show ISL1 Proteins)>POU4F1 (show POU4F1 Proteins)>POU4F2 during the inner ear neurogenesis.
The cloning and expression profile of brn-3b in the zebrafish (Danio rerio) were assessed as the first step for understanding its role in the development of sensory systems.
member of the POU family of transcription factors\\\\; play key roles in the development of specific neuronal cell types
Brn3b POU domain transcription factor
, POU domain class 4 transcription factor 2
, POU domain protein
, POU domain, class 4, transcription factor 2
, brain-specific homeobox/POU domain protein 3B
, POU domain, class 4, transcription factor, related sequence 1
, POU class 4 homeobox 2
, POU-homeodomain protein