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Results indicate a role for the RNA processing factors THRAP3 and BCLAF1 (show BCLAF1 ELISA Kits) in the regulation of the cellular DNA damage response (DDR (show DDR1 ELISA Kits)) pathway.
The data suggest a model in which TRAP150 interacts with dimeric PSF (show IGFBP7 ELISA Kits) to block access of RNA to RRM2 (show RRM2 ELISA Kits), thereby regulating the activity of PSF (show IGFBP7 ELISA Kits) toward a broad set of splicing events in T cells.
Thrap3 plays a crucial role in controlling diabetic gene programming and may provide opportunities for the development of new therapeutics for obesity and type 2 diabetes.
BTF (show BCLAF1 ELISA Kits) has functions distinct from TRAP150 in regulating the subcellular distribution of mRNAs in human cells.
Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
Data indicate that distinct differences in proteins becoming Poly(ADP-ribose) PARylated upon various genotoxic insults are observed, exemplified by the PARylation of RNA-processing factors THRAP3 and TAF15 under oxidative stress.
THRAP3 has a rold in the DNA damage response.
TFIID (show TBP ELISA Kits) and human mediator coactivator (TRAP150) complexes assemble cooperatively on promoter DNA
TRAP150 is a selective coactivator for CLOCK-BMAL1 (show ARNTL ELISA Kits), promoting its binding to target genes and linking it to the transcriptional machinery at target-gene promoters.
Plays a role in transcriptional coactivation (By similarity).
DNA cross-link repair 1A protein
, DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)
, DNA-crosslink repair gene SNM1
, thyroid hormone receptor associated protein 3
, thyroid hormone receptor-associated protein 3
, thyroid hormone receptor-associated protein complex 150 kDa component
, thyroid hormone receptor-associated protein, 150 kDa subunit