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|Antigen||Interferon, beta 1, Fibroblast (IFNB1) Antibodies|
|Conjugate||This IFNB1 antibody is un-conjugated Alternatives|
Functional Studies (Func), Immunoprecipitation (IP), Western Blotting (WB)
|3 references available|
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Product Details anti-IFNB1 AntibodyTarget Details IFNB1 Application Details Handling References for anti-IFNB1 antibody (ABIN121882) Images
|Specificity||This antibody recognizes Interferon beta (chIFN-beta). This antibody does not cross react with IFN gamma. This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities.|
|Characteristics||Synonyms: IFN-beta, IFNB1, IFB, Fibroblast interferon|
|Purification||Affinity chromatography on protein G|
|Immunogen||Recombinant chicken Interferon Beta|
Target Details IFNB1Product Details anti-IFNB1 Antibody Application Details Handling References for anti-IFNB1 antibody (ABIN121882) Images back to top
|Alternative Name||IFNB / Interferon beta (IFNB1 Antibody Abstract)|
|Background||Reports suggest that chIFN exhibits properties similar to mammalian IFN type I (IFNI). Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately tenfold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy|
Application DetailsProduct Details anti-IFNB1 Antibody Target Details IFNB1 Handling References for anti-IFNB1 antibody (ABIN121882) Images back to top
Immunoprecipitation. Western Blot: This antibody detects a band of approximately 20 kDa. Funktional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IFNB1 Antibody Target Details IFNB1 Application Details References for anti-IFNB1 antibody (ABIN121882) Images back to top
Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-IFNB1 antibody (ABIN121882)Product Details anti-IFNB1 Antibody Target Details IFNB1 Application Details Handling Images back to top
Schwarz, Harlin, Ohnemus, Kaspers, Staeheli: "Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 24, Issue 3, pp. 179-84, 2004
Staeheli, Puehler, Schneider, Göbel, Kaspers: "Cytokines of birds: conserved functions--a largely different look." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 21, Issue 12, pp. 993-1010, 2002
Sick, Schultz, Staeheli: "A family of genes coding for two serologically distinct chicken interferons." in: The Journal of biological chemistry, Vol. 271, Issue 13, pp. 7635-9, 1996