anti-Human IFNB1 antibody for Functional Studies

Recommended IFNB1 Antibody (supplied by: Log in to see )

Antigen
Interferon, beta 1, Fibroblast (IFNB1) Antibodies
  • IFB
  • IFF
  • IFNB
  • IFN-beta
  • Ifb
  • Ifnb
  • IFNb
  • interferon beta 1
  • interferon beta 1, fibroblast
  • interferon, beta 1, fibroblast
  • interferon omega 1
  • IFNB1
  • Ifnb1
  • IFNW1
Reactivity
Human
286
41
20
20
13
11
9
7
7
3
3
1
Host
Sheep
197
169
8
6
4
3
3
Clonality
Polyclonal
Conjugate
This IFNB1 antibody is un-conjugated
37
27
12
8
8
5
5
5
4
4
4
4
4
4
4
4
4
4
3
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func)
333
230
117
63
30
29
24
19
17
16
15
14
9
9
5
4
2
2
2
2
1
Supplier
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Catalog No. ABIN318982
$ 665.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN181770 EIA Func IHC (p) WB Rabbit Log in to see Polyclonal 0
1 ABIN116507 EIA Func IHC (p) WB Rabbit Log in to see Polyclonal 0
1 ABIN189793 Func IHC (fro) IP ELISA WB Mouse IgG3 Log in to see MMHB-13 0
1 ABIN189788 Func IHC (fro) IP ELISA WB Mouse IgG2a Log in to see MMHB-3 0
1 ABIN189790 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-1 0
1 ABIN189791 Func ELISA WB Mouse IgG1 Log in to see MMHB-2 0
1 ABIN189792 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-12 0
1 ABIN189794 Func IHC (fro) IP ELISA WB Mouse IgG2b Log in to see MMHB-14 0
1 ABIN189795 Func IHC (fro) IP ELISA WB Mouse IgG2a Log in to see MMHB-15 0
1 ABIN189796 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-16 0
1 ABIN189789 Func FACS IHC (fro) ELISA FITC Mouse IgG1 Log in to see MMHB-3 0
1 ABIN189835 Func IHC (fro) IP ELISA WB Rabbit Log in to see Polyclonal 0

General

Antigen Interferon, beta 1, Fibroblast (IFNB1) Antibodies
Reactivity Human
(286), (41), (20), (20), (13), (11), (9), (7), (7), (3), (3), (1)
Host Sheep
(197), (169), (8), (6), (4), (3), (3)
Clonality
Polyclonal
Conjugate This IFNB1 antibody is un-conjugated
(37), (27), (12), (8), (8), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func)
(333), (230), (117), (63), (30), (29), (24), (19), (17), (16), (15), (14), (9), (9), (5), (4), (2), (2), (2), (2), (1)
Pubmed 5 references available
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Product Details anti-IFNB1 Antibody

Target Details IFNB1 Application Details Handling References for anti-IFNB1 antibody (ABIN318982) Images
Specificity This antiobdy is specific for human IFN-beta. This antibody has not bee cross-adsorbed and may react with related peptides from other species.
Immunogen Recombinant human interferon beta (IFN-beta) derived from E. coli.
Isotype IgG
Plasmids, Primers & others

Target Details IFNB1

Product Details anti-IFNB1 Antibody Application Details Handling References for anti-IFNB1 antibody (ABIN318982) Images back to top
Antigen
Alternative Name IFNB / Interferon beta (IFNB1 Antibody Abstract)
Background The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1
Gene ID 15977
NCBI Accession NP_034640
UniProt P01575
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy

Application Details

Product Details anti-IFNB1 Antibody Target Details IFNB1 Handling References for anti-IFNB1 antibody (ABIN318982) Images back to top
Application Notes Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-IFNB1 Antibody Target Details IFNB1 Application Details References for anti-IFNB1 antibody (ABIN318982) Images back to top
Buffer Phosphate buffered saline
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C

References for anti-IFNB1 antibody (ABIN318982)

Product Details anti-IFNB1 Antibody Target Details IFNB1 Application Details Handling Images back to top
Background publications

Dansky-Ullmann, Salgaller, Adams, Schlom, Greiner: "Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-beta." in: Cytokine, Vol. 7, Issue 2, pp. 118-29, 1995

Dhib-Jalbut, Cowan: "Direct evidence that interferon-beta mediates enhanced HLA-class I expression in measles virus-infected cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 11, pp. 6248-58, 1994

Chen, Innis, Sun, Wright, Kellems: "Sequence requirements for transcriptional arrest in exon 1 of the human adenosine deaminase gene." in: Molecular and cellular biology, Vol. 11, Issue 12, pp. 6248-56, 1991

Familletti, Rubinstein, Pestka: "A convenient and rapid cytopathic effect inhibition assay for interferon." in: Methods in enzymology, Vol. 78, Issue Pt A, pp. 387-94, 1982

Rubinstein, Familletti, Pestka: "Convenient assay for interferons." in: Journal of virology, Vol. 37, Issue 2, pp. 755-8, 1981