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|Antigen||Interleukin 4 (IL4) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL-4 antibody is un-conjugated Alternatives|
Blocking Antibody (Inhibition), ELISA, Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-IL-4 AntibodyTarget Details IL-4 Application Details Handling Images
|Immunogen||IL4 antibody was raised in rabbit using highly pure recombinant murine IL-4 as the immunogen.|
Target Details IL-4Product Details anti-IL-4 Antibody Application Details Handling Images back to top
|Alternative Name||IL4 (IL4 Antibody Abstract)|
|Background||IL4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL4, IL5, IL6, IL10, and IL13, which favor a humoral immune response. Another dominant function of IL4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL4 production by Th2 cells has been associated with elevated IgE production and allergy.|
|Molecular Weight||14 kDa (predicted detection band MW)|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation|
Application DetailsProduct Details anti-IL-4 Antibody Target Details IL-4 Handling Images back to top
ELISA: 0.5-2 µg/mL, Inhibition: 0.78-1.16 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-4 Antibody Target Details IL-4 Application Details Images back to top
|Reconstitution||Reconstitute in sterile water to a concentration > 0.2 mg/mL.|
|Buffer||Lyophilized from PBS, pH 7.4.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.|