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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN803868
Pacheco, Oliva, Martinez-Navío, Climent, Ciruela, Gatell, Gallart, Mallol, Lluis, Franco: Glutamate released by dendritic cells as a novel modulator of T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130
McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127
Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986
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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126
Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN804054
Pacheco, Martinez-Navio, Lejeune, Climent, Oliva, Gatell, Gallart, Mallol, Lluis, Franco: CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. in Proceedings of the National Academy of Sciences of the United States of America 2005
Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839
Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013
Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1888633
Osusky, Teschke, Wang, Wong, Buckley: A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor. in The Journal of biological chemistry 2008
Human IL-4 Protein expressed in HEK-293 Cells - ABIN2181318
Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. in Immunological reviews 2004
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Human CCL1 (show CCL1 Proteins) gene is selectively targeted by AhR (show AHR Proteins) in M(IL-4) macrophage. IL-4-induced epigenetic modification potentiates AhR (show AHR Proteins)-mediated CCL1 (show CCL1 Proteins) expression.
Liver IL-4 mRNA is downregulated in patients with pancreatic cancer and cachexia.
Low IL4 expression is associated with melanoma.
Cytokines (IFNg (show IFNG Proteins) and IL-4) estimation was done in the blood and NPA samples of cases and blood samples of controls.The mean levels of interleukin-4 in controls (blood), and cases (NPA and blood) were 1280.77, 956.08 and 692.37 pg/ml, respectively (P<0.05).
In this review, we discuss the molecular mechanisms driving IL-4 production in Th2 and Tfh cells.
In this review, we discuss the structural details of IL-4 and IL-4Ralpha subunit and the structural similarities between IL-4 and IL-13 (show IL13 Proteins). We also describe detailed chemistry of type-I and type-II receptor complexes and their signaling pathways. Furthermore, we elaborate the strength of type-II hetero dimer signals in response to IL-4 and IL-13 (show IL13 Proteins).
The obtained data demonstrate that the high level of production of IL-1b (show IL1B Proteins) and IL-4 in GN patients causes hypothyroidism resulting in the formation of nephrotic syndrome.
IL-4 and IL-17 (show IL17A Proteins) modulate the functional activity of phagocytes in the maternal blood, cord blood, and colostrum of diabetic mother.
Results showed that plasma and mRNA levels of IL-2 (show IL2 Proteins), IFN-gamma (show IFNG Proteins), IL-4, and IL-17A (show IL17A Proteins) in primary immune thrombocytopenia patients did not change significantly after TPO (show THPO Proteins)-RA treatment, whereas TGF-beta1 (show TGFB1 Proteins) levels increased remarkably.
Modulation of IL-2 (show IL2 Proteins), IL-4, IFN-gamma (show IFNG Proteins) and/or TNF-alpha (show TNF Proteins) levels, or inhibitors of Erk1/2 or S6K1 (show RPS6KB1 Proteins) may be a new approach to prevent BAFF (show TNFSF13B Proteins)-induced aggressive B-cell malignancies.
In the lung, surfactant protein A (show GPR153 Proteins) (SP-A (show SFTPA1 Proteins)) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection.
Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.
NK cells activated by IL-4 in cooperation with IL-15 (show IL15 Proteins) exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
we defined a molecular mechanism for IL-4 downregulation of involucrin (show IVL Proteins) in keratinocytes, which may play an important role in the pathogenesis of AD.
In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 (show CCL2 Proteins) signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model
T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.
Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.
this study shows that environmental IL-4 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 and IL-13 (show IL13 Proteins) are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
These observations suggest that IL-4 and IL-13 (show IL13 Proteins) likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (show HAND1 Proteins) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG Proteins) occurring after parturition and an increase in IL-4 production before calving.
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
IL-4- and IL-10 (show IL10 Proteins)-producing invariant NKT (show SLC22A6 Proteins) cells inhibit the Th1 (show TH1L Proteins) cell response, but not the Th17 cell response
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.
The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.
unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 Proteins) secretion and suppresses antigen-stimulated proliferation of B cells
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IL-4 and STAT6 (show STAT6 Proteins) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 Proteins).
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, B cell growth factor 1
, B_cell stimulatory factor 1
, lymphocyte stimulatory factor 1
, B-cell IgG differentiation factor
, B-cell growth factor 1
, B-cell stimulatory factor 1
, IGG1 induction factor
, B-cell IGG differentiation factor
, Lymphocyte stimulatory factor 1