Browse our IL-4 Proteins (IL4)

Human Interleukin 4 (IL4) interaction partners

1. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (IL-4, Il-10, TGFB1) occurs in women with endometriosis. (Review)

2. IL4 SNPs were not associated with the risk of endometrial cancer in Chinese Han women.

3. GWA study indicated potential associations between IL-4 polymorphisms and lung cancer susceptibility in China.

4. result showed that the RP2/RP2 genotype of the IL-4 VNTR polymorphism could be a protective factor for breast cancer susceptibility

5. rs2243283 in the IL-4gene was potentially associated with an increased risk of steroid-induced osteonecrosis of the femoral head in Chinese population.

6. There was a significant statistical difference as regards 70 Base pair variable numbers of tandem repeats of IL-4 gene genotype distribution on comparing the two studied groups with increased frequency of the B2B2 genotype 70% versus 33.3 and B2 allele 83% versus 60% in group I, B2B2 genotype increases the risk of diabetes mellitus by sevenfolds and B2 allele increases the risk by 3.25 folds

7. The results indicated possible role of this cryptic allosteric site in IL-4/IL-4R signaling pathway that might help us to block IL-4/IL-4R association to prevent various allergic and malignant diseases.

8. The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with primary progressive multiple sclerosis in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.

9. associations between CD40L/IL-4 response and baseline ATM levels, induction of ATM, and phosphorylation of the ATM targets, p53 and H2AX. X-irradiation was used to demonstrate that CD40L/IL-4 stimulation tended to improve DNA damage repair.

10. that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro

11. The results indicate IL-13 SNP rs1800925 as a risk factor for CRC and that IL-4 SNP rs2243250 could be a useful prognostic marker in the follow-up and clinical management of patients with CRC especially in stage III disease.

12. IL4 rs2243250 is not associated with Diabetic nephropathy in our subset of Slovenian patients with type 2 diabetes mellitus

13. Combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery.

14. IL4 induces CCL17 production by acting through IRF4 in human monocytes and murine macrophages.

15. findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function

16. A microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis.

17. IL-33 has a role in the pathogenesis of autoimmune hepatitis (AIH) and affects the expression of IL-4, IL-17A, and of hypergammaglobulinemia

18. Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics.

19. Allelic polymorphism C590T of the gene IL-4 is the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children.

20. certain single nucleotide polymorphisms of IL4 gene could predispose individuals to recurrent aphthous stomatitis

Mouse (Murine) Interleukin 4 (IL4) interaction partners

1. During clearance of Citrobacter rodentium infection infection, the concomitant increase in IL-4 protects and maintains goblet cell function against the increasing levels of TNF-alpha and IFN-gamma

2. that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro

3. High IL6 expression is associated with emphysema development in Chronic obstructive pulmonary disease.

4. IL4 induces CCL17 production by acting through IRF4 in human monocytes and murine macrophages.

5. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils.

6. thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development; findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function

7. A microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis

8. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.

9. Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells

10. IL-4/ STAT6 signaling needs to be well adjusted to ensure proper development and function of homing Th2 cells.

11. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13.

12. The VEGFR1-mediated signaling suppressed IL-4-induced Arg-1 expression.

13. The results obtained in the present study suggest that a signaling pathway mediated by FcRg or the FcRg-Syk axis is commonly required for innate basophil IL-4 responses under conditions mimicking encounters with allergen sources.

14. IL-4Delta2 did not compete with IL-4 for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.

15. this study shows that IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation

16. The complex role of IL-4 in autoimmunity and cholangitis.

17. The results demonstrate that IL-4 can restore insulin sensitivity in adipocytes via mechanisms not associated with induced adipogenesis or de novo formation of lipid depots.

18. Interleukin 4 (IL-4) signaling prevents Chlamydia trachomatis Infection from Inducing upper genital tract (UGT) pathology.

19. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection.

20. Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.

Cow (Bovine) Interleukin 4 (IL4) interaction partners

1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.

2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

1. IL-4- and IL-10-producing invariant NKT cells inhibit the Th1 cell response, but not the Th17 cell response

2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

2. IL-4 and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.

Rhesus Monkey Interleukin 4 (IL4) interaction partners

1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.