Browse our IL-4 Proteins (IL4)

Human Interleukin 4 (IL4) interaction partners

1. findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function

2. A microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis.

3. IL-33 has a role in the pathogenesis of autoimmune hepatitis (AIH) and affects the expression of IL-4, IL-17A, and of hypergammaglobulinemia

4. Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics.

5. Allelic polymorphism C590T of the gene IL-4 is the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children.

6. certain single nucleotide polymorphisms of IL4 gene could predispose individuals to recurrent aphthous stomatitis

7. results suggest, the interplay of pro-inflammatory cytokines IFN-gamma derived from CD4+T lymphocytes and TNF-alpha from CD14+ cells has no direct additive impact on parasite replication but induces IL-4 production.

8. Germline variants in IL4 gene are associated with prostate cancer.

9. The role of IL-4 in psoriasis.

10. serum IP-10 level and the IFN-gamma/IL-4 ratio have great potential to predict significant fibrosis among chronic hepatitis B patients.

11. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13.

12. IL-4 polymorphisms might be associated with Kawasaki disease in an Iranian population.

13. association between root resorption and IL4 gene polymorphisms was observed.

14. these results demonstrated that variable number tandem repeat polymorphism in the IL-4 gene is associated with diabetic peripheral neuropathy in type 2 diabetes patients with coexisting cardiovascular disease

15. serum antibodies against HP-NAP represent a state of risk, which is further exacerbated in IL-4 -590 T carriers.

16. Polymorphisms at IL10 (-1082 G>A), IL4 (-589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases.

17. Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls.

18. The results confirmed that the IL-4-590C/T polymorphism is correlated with the onset of RA and that carrying the T-allele can significantly increase the risk of rheumatoid arthritis in the Chinese Han population.

19. the IL-4-590 C>T polymorphism does not influence the development of head and neck cancer.

20. the present study suggests that IL-4 polymorphisms might play a role in susceptibility to inflammatory bowel disease and its major subtypes in the Iranian population

Mouse (Murine) Interleukin 4 (IL4) interaction partners

1. thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development; findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function

2. A microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis

3. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.

4. Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells

5. IL-4/ STAT6 signaling needs to be well adjusted to ensure proper development and function of homing Th2 cells.

6. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13.

7. The VEGFR1-mediated signaling suppressed IL-4-induced Arg-1 expression.

8. The results obtained in the present study suggest that a signaling pathway mediated by FcRg or the FcRg-Syk axis is commonly required for innate basophil IL-4 responses under conditions mimicking encounters with allergen sources.

9. IL-4Delta2 did not compete with IL-4 for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.

10. this study shows that IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation

11. The complex role of IL-4 in autoimmunity and cholangitis.

12. The results demonstrate that IL-4 can restore insulin sensitivity in adipocytes via mechanisms not associated with induced adipogenesis or de novo formation of lipid depots.

13. Interleukin 4 (IL-4) signaling prevents Chlamydia trachomatis Infection from Inducing upper genital tract (UGT) pathology.

14. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection.

15. Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.

16. NK cells activated by IL-4 in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.

17. we defined a molecular mechanism for IL-4 downregulation of involucrin in keratinocytes, which may play an important role in the pathogenesis of AD.

18. In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model

19. T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.

20. Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.

Cow (Bovine) Interleukin 4 (IL4) interaction partners

1. These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.

2. IL-4 may play a role in coordinating the adrenal response to inflammatory stress.

3. T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.

Pig (Porcine) Interleukin 4 (IL4) interaction partners

1. IL-4- and IL-10-producing invariant NKT cells inhibit the Th1 cell response, but not the Th17 cell response

2. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

3. There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.

4. The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.

5. unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 secretion and suppresses antigen-stimulated proliferation of B cells

Guinea Pig Interleukin 4 (IL4) interaction partners

1. Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.

2. IL-4 and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.

Horse (Equine) Interleukin 4 (IL4) interaction partners

1. The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.

2. This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.

Rhesus Monkey Interleukin 4 (IL4) interaction partners

1. Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.

2. Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.