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|Antigen||Interleukin-6 Receptor (IL6R) Antibodies|
|Epitope||AA 44-357 Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL-6 Receptor antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-IL-6 Receptor AntibodyTarget Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2000701) Images
|Specificity||Mouse IL6RA / CD126|
|Characteristics||Produced in rabbits immunized with purified, recombinant Mouse IL6RA / CD126 (rM IL6RA, ABIN2007611 NP_034689.2, Ile 44-Glu 357,. IL6RA specific IgG was purified by mouse IL6RA affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse IL6RA protein (ABIN2007611)|
Target Details IL-6 ReceptorProduct Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2000701) Images back to top
|Alternative Name||IL6R (IL6R Antibody Abstract)|
|Background||Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.|
|Pathways||JAK-STAT Signaling, Autophagy, Growth Factor Binding|
Application DetailsProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor antibody (ABIN2000701) Images back to top
WB: 10-20 μg/mL
ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse IL6RA. The detection limit for Mouse IL6RA is 0.00245 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor antibody (ABIN2000701) Images back to top
|Buffer||0.2 μm filtered solution in PBS|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
References for anti-IL-6 Receptor antibody (ABIN2000701)Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Stauber, Barill, Stauber, Miller: "Isotonic dynamometry for the assessment of power and fatigue in the knee extensor muscles of females." in: Clinical physiology (Oxford, England), Vol. 20, Issue 3, pp. 225-33, 2000
ImagesProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2000701) back to top