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|Antigen||Interleukin 12b (IL12B) Antibodies|
|Epitope||AA 23-250 Alternatives|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IL12B antibody is un-conjugated Alternatives|
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|1 reference available|
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Product Details anti-IL12B AntibodyTarget Details IL12B Application Details Handling References for anti-IL12B antibody (ABIN5519010) Images
|Purpose||Rabbit IgG polyclonal antibody for IL12B detection. Tested with WB, IHC-P, Direct ELISA in Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for IL12B detection. Tested with WB, IHC-P, Direct ELISA in Mouse,Rat.
Gene Name: interleukin 12B
Protein Name: Interleukin-12 subunit beta
|Purification||Immunogen affinity purified.|
|Immunogen||E. coli-derived rat IL12B recombinant protein (Position: M23-E250).|
|Plasmids, Primers & others|
Target Details IL12BProduct Details anti-IL12B Antibody Application Details Handling References for anti-IL12B antibody (ABIN5519010) Images back to top
|Alternative Name||Il12b (IL12B Antibody Abstract)|
Subunit beta of interleukin 12 (IL12B), also known as interleukin 12B, or interleukin-12 subunit p40, is a subunit of human interleukin 12. It is mapped to 5q33.3. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.
Synonyms: Interleukin-12 subunit beta
|Pathways||JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation|
Application DetailsProduct Details anti-IL12B Antibody Target Details IL12B Handling References for anti-IL12B antibody (ABIN5519010) Images back to top
|Application Notes||Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.|
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL12B Antibody Target Details IL12B Application Details References for anti-IL12B antibody (ABIN5519010) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-IL12B antibody (ABIN5519010)Product Details anti-IL12B Antibody Target Details IL12B Application Details Handling Images back to top
|Product cited in:||
Dong, Xia, Chen, Chen, Zhang: "Anti-arthritis activity of cationic materials." in: Journal of cellular and molecular medicine, Vol. 14, Issue 7, pp. 2015-24, 2011
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