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|Antigen||Interleukin 2 (IL2) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL2 antibody is un-conjugated Alternatives|
Functional Studies (Func)
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Product Details anti-IL2 AntibodyTarget Details IL2 Application Details Handling Images
|Specificity||This antibody reacts to IL-2. Does not cross react with rat or human IL-2.|
|Characteristics||Synonyms: IL-2, TCGF, T-cell growth factor|
|Immunogen||Mouse IL-2 purified from Con A activated T cell supernatant|
Target Details IL2Product Details anti-IL2 Antibody Application Details Handling Images back to top
|Alternative Name||Interleukin-2 / IL2 (IL2 Antibody Abstract)|
|Background||Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation|
Application DetailsProduct Details anti-IL2 Antibody Target Details IL2 Handling Images back to top
A 1: 50 dilution will block 50 - 70 % of CTLL proliferative response to 5 % Con A sup as asource for mouse IL-2. This antibody will also block 50 - 70 % of MLR or T cell proliferationto KLH
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2 Antibody Target Details IL2 Application Details Images back to top
|Reconstitution||Restore with 0.2 mL water. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.|
|Concentration||1,0 mg/mL (prior to lyophilization)|
|Storage||4 °C/-20 °C|
Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|