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sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS.
Relationship between soluble CD25 (show IL2RA Proteins) and gene expression in healthy individuals and patients with multiple sclerosis.
Increased serum level of soluble interleukin-2 (show IL2 Proteins) receptor is associated with a worse response of metastatic clear cell renal cell carcinoma (show MOK Proteins) to interferon alpha (show IFNA Proteins) and sequential VEGF (show VEGFA Proteins)-targeting therapy.
Data show that interleukin-2 receptor alpha (show IL2RA Proteins), tumor necrosis factor receptor 1 (show TNFRSF1A Proteins), serum STimulation-2 (IL1RL1 (show IL1RL1 Proteins) gene product), and regenerating islet-derived 3-alpha (show REG3A Proteins) were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 (show IL2RA Proteins) expression and altered IL-2 (show IL2 Proteins) signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA (show IL2RA Proteins) expression is associated with CRLF2 (show CRLF2 Proteins)-rearranged acute lymphoblastic leukemia.
Inhibits CD25 (show IL2RA Proteins) translation through regulation of the LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 (show IL2RA Proteins) expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 (show IL2RA Proteins) expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA (show IL2RA Proteins) in men.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha