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Relationship between soluble CD25 (show IL2RA Proteins) and gene expression in healthy individuals and patients with multiple sclerosis.
Increased serum level of soluble interleukin-2 (show IL2 Proteins) receptor is associated with a worse response of metastatic clear cell renal cell carcinoma (show MOK Proteins) to interferon alpha (show IFNA Proteins) and sequential VEGF (show VEGFA Proteins)-targeting therapy.
Data show that interleukin-2 receptor alpha (show IL2RA Proteins), tumor necrosis factor receptor 1 (show TNFRSF1A Proteins), serum STimulation-2 (IL1RL1 (show IL1RL1 Proteins) gene product), and regenerating islet-derived 3-alpha (show REG3A Proteins) were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 (show IL2RA Proteins) expression and altered IL-2 (show IL2 Proteins) signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA (show IL2RA Proteins) expression is associated with CRLF2 (show CRLF2 Proteins)-rearranged acute lymphoblastic leukemia.
Inhibits CD25 (show IL2RA Proteins) translation through regulation of the LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 (show IL2RA Proteins) expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 (show IL2RA Proteins) expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA (show IL2RA Proteins) in men.
it has been shown that CD25 (show IL2RA Proteins) serves as a negative growth regulator of Chronic myeloid leukemia (show BCL11A Proteins) leukemic stem cells.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha