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|Antigen||Interleukin 2 Receptor, gamma (IL2RG) Antibodies|
|Epitope||AA 1-263 Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL2RG antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
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Product Details anti-IL2RG AntibodyTarget Details IL2RG Application Details Handling Images
|Specificity||Mouse CD132 / IL2RG|
|Characteristics||Produced in rabbits immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG, ABIN2007301 NP_038591.1, Met 1-Ala 263,. CD132 / IL2RG specific IgG was purified by Mouse CD132 / IL2RG affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse CD132 / IL2RG protein (ABIN2007301)|
|Plasmids, Primers & others|
Target Details IL2RGProduct Details anti-IL2RG Antibody Application Details Handling Images back to top
|Alternative Name||IL2RG (IL2RG Antibody Abstract)|
|Background||The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.|
|Pathways||JAK-STAT Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-IL2RG Antibody Target Details IL2RG Handling Images back to top
WB: 10-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL2RG. The detection limit for Mouse IL2RG is approximately 0.00245 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
ImagesProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling back to top