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Gene IL6R (show IL6R Proteins) polymorphic variant rs2228145(C>A) seems to be involved in genetic predisposition of the population of Karelia to nonalcoholic steatohepatitis.
Frequency of IL-6R TT (rs4129267) genotype was increased in Ankylosing Spondylitis patients. Interleukin IL-6R (rs4129267) gene polymorphisms could serve as promising biomarkers for diagnosis and prognosis in Ankylosing Spondylitis patients.
In a genome-wide meta-analysis of 20,550 patients with Crohn's disease (CD), 17,647 patients with ulcerative colitis (UC), and more than 40,000 individuals without IBD (controls), study found that rs2228145 (scaled to a 2-fold increase in s-IL6R (show IL6R Proteins)) was associated with reduced risk of CD or UC.[meta-analysis]
Data (including data from studies using transgenic/knockout mice) suggest that signaling via IL6 (show IL6 Proteins)/IL6R (show IL6R Proteins) couples autophagy to antioxidant response in insulin (show INS Proteins)-secreting cells. (IL6 (show IL6 Proteins) = interleukin-6 (show IL6 Proteins); IL6R (show IL6R Proteins) = interleukin-6 receptor (show IL6ST Proteins))
Analysis of the IL-6 (show IL6 Proteins) (-572G/C) polymorphism revealed a higher level of the GG genotype in the patients with Celiac Disease compared with the control group.
miR (show MLXIP Proteins)-124, IL-6R and STAT3 (show STAT3 Proteins) are involved in the process of sulforaphane-improved CDDP chemotherapy efficacy by targeting cancer stem cell-like properties
High IL6 (show IL6 Proteins)-R expression is associated with cisplatin resistance in epithelial ovarian cancer.
An increase in soluble IL-6R in peritoneal fluid promotes the development of endometriosis by enhancing the bioactivity of IL-6 (show IL6 Proteins).
sIL (show PMEL Proteins)-6R may be a useful biomarker to assess insulin (show INS Proteins) resistance among morbidly obese subjects
Study identified variants associated with the age of onset of Alzheimer's disease in APOE (show APOE Proteins) varepsilon4 carriers. Across five datasets, p.D358A had a meta P = 3 x10-4 and an odds ratio = 1.3, 95% confidence interval 1.12 -1.48. Study suggests that a common coding region variant of the IL-6 (show IL6 Proteins) receptor results in neuroinflammatory changes that may influence the age of onset of Alzheimer's disease in APOE (show APOE Proteins) varepsilon4 carriers.
Data (including data from studies using transgenic/knockout mice) suggest that signaling via IL6 (show IL6 Proteins)/IL6R (show IL6R Proteins) couples autophagy to antioxidant response in insulin (show INS Proteins)-secreting cells. (IL6 (show IL6 Proteins) = interleukin-6 (show IL6 Proteins); IL6R (show IL6R Proteins) = interleukin-6 receptor (show IL6R Proteins))
In the CNS, LPS (show TLR4 Proteins) administration had the greatest effect on IL-6R mRNA.
IL-6 (show IL6 Proteins) Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 (show ING4 Proteins) to the tumor.
role for IL-6R expression in regulating RBC (show CACNA1C Proteins) alloimmunization
There are functional interleukin-6 receptor-alpha (show IL6R Proteins) on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (show IL6 Proteins) decreases obesity in mice via an effect on this cell type.
we present evidence for the role of M2 phenotype TAM (show CCNA1 Proteins) in IL-6 (show IL6 Proteins) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (show STAT3 Proteins), responsible for the prosurvival adaptation of tumor cells to hypoxia.
TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha (show IL6R Proteins) may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain