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In the present study, the authors show that deletion of a triple serine (3S) motif (Ser (show SIGLEC1 Proteins)-359 to Ser (show SIGLEC1 Proteins)-361) adjacent to the cleavage site is sufficient to prevent IL-6R cleavage by ADAM17 (show ADAM17 Proteins), but not ADAM10 (show ADAM10 Proteins). We find that the impaired shedding is caused by the reduced distance between the cleavage site and the plasma membrane.
IL6R (show IL6R Proteins) SNPs are associated with simultaneously high CRP (show CRP Proteins), LDL and ApoB (show APOB Proteins) levels.
The sgp130, IL-6 (show IL6 Proteins), and sIL (show PMEL Proteins)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (show IL6 Proteins) trans-signaling pathway to the pathophysiology of DR.
The mRNA expression of IL6R (show IL6R Proteins) was inversely correlated with miR (show MLXIP Proteins)-449a in osteosarcoma tissues. In addition, JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway was regulated by circ_0009910/miR (show MLXIP Proteins)-449a/IL6R (show IL6R Proteins) axis.
IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis
study demonstrates enhanced T cell responses to IL-6 (show IL6 Proteins) in T1D due, in part, to an increase in IL-6R surface expression. Dysregulated IL-6 (show IL6 Proteins) responsiveness may contribute to diabetes through multiple mechanisms including altered T cell trafficking
Enterovirus 71 antagonizes the antiviral activity of host STAT3 (show STAT3 Proteins) and IL-6R with partial dependence on virus-induced miR (show MLXIP Proteins)-124.
we present evidence for the role of M2 phenotype TAM (show CCNA1 Proteins) in IL-6 (show IL6 Proteins) receptor-mediated signals, particularly tyrosine phosphorylation of STAT3 (show STAT3 Proteins), responsible for the prosurvival adaptation of tumor cells to hypoxia.
3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor (show IL6ST Proteins) [IL6R (show IL6R Proteins)] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19 (show Adam19 Proteins)]) were associated with a lower risk of suffering the most severe stages of the disease.
The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 (show IL6 Proteins) signaling and asthma risk.
There are functional interleukin-6 receptor-alpha (show IL6R Proteins) on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 (show IL6 Proteins) decreases obesity in mice via an effect on this cell type.
TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Interleukin-6 receptor alpha (show IL6R Proteins) may have a role in skin lesions in a murine model of systemic lupus erythematosus
findings identify TRAF3 (show TRAF3 Proteins) and PTPN22 (show PTPN22 Proteins) as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 (show TRAF3 Proteins) in the regulation of plasma cell differentiation
Data show that blockade of interleukin-6 receptor (show IL6R Proteins) by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs (show UGCG Proteins)) and inhibit the bone loss they cause.
established that endogenous IL-6R of both human and murine origin is shed by ADAM17 (show ADAM17 Proteins) in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 (show ADAM10 Proteins)
Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
When endogenously released IL-6 (show IL6 Proteins) binds to Il-6Ralpha (show IL6R Proteins) in brain the effect is pyrogenic.
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
IL-6 receptor subunit alpha
, IL-6R 1
, IL-6R subunit alpha
, interleukin 6 receptor, alpha
, interleukin-6 receptor subunit alpha
, CD126 antigen
, membrane glycoprotein 80
, IL-6 receptor alpha chain