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Results show that silencing of the IL-9R gene alleviates the drug resistance of diffuse large B-cell lymphoma (DLBCL) cell lines that is induced by IL-9 (show IL9 Proteins) suggesting that IL-9R is involved in chemotherapy drug resistance of DLBCL.
in PsA patients gammadelta T cells activation is driven prevalently by IL-9/IL-9R interaction, and not only by IL-23/IL-23R. Together these findings indicate gammadelta T cells and IL-9 as new players in the pathogenesis of PsA.
The findings indicated that IL-9R was constitutively expressed and exerted a tumor-promoting effect in hepatocellular carcinoma, whose expression level may be a useful biomarker of tumor invasiveness and patient clinical outcome.
Confocal microscopy and fluorescence resonance energy transfer experiments revealed nonrandom association of IL-9R with IL-2R/major histocompatibility complex glycoproteins at the surface of human T lymphoma cells.
Low expression of CD39 (show ENTPD1 Proteins)(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101 (show CD101 Proteins)(+) /CD129(+) on Treg cells in children with coeliac disease.
Mice with PU.1 deficiency in T cells were protected from colitis, whereas treatment with antibody to IL-9 (show IL9 Proteins) suppressed colitis
Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of diffuse large B-cell lymphoma
One of the identified peptide sequences corresponded to a fragment of the human interleukin-9 receptor alpha (IL-9Ralpha).
analysis of IL-9 (show IL9 Proteins) and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population
There is an association of at least 2 X-chromosomal genes with rheumatoid arthritis: TIMP1 (show TIMP1 Proteins) and IL9R.
Data indicate that increased expression of interleukin-9 receptor (Il9R) is associated with an increased binding of nucleolin (show NCL Proteins).
These results suggest that the unusual expression of interleukin-9 (show IL9 Proteins) receptors and/or increased responsiveness of thymocytes to cytokines are key processes in the development of radiation-induced T cell lymphomas.
These data suggest that IL-9/IL-9 (show IL9 Proteins) receptor signaling pathway represents a novel endogenous antiapoptotic mechanism for cortical neurons by controlling JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) and Bax (show BAX Proteins) levels.
IL-9Ralpha and IL-2Rbeta (show IL2RB Proteins) homodimers efficiently mediate constitutive activation of ALL-associated JAK1 (show JAK1 Proteins) mutants.
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene.
, interleukin-9 receptor