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anti-Human JAK2 Antibodies:
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Human JAK2 Primary Antibody for IHC - ABIN966430
Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. in Molecular and cellular biology 2004
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Human Monoclonal JAK2 Primary Antibody for ELISA, WB - ABIN966429
Mol, de Rijke, Demacker, Stalenhoef: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. in Atherosclerosis 1997
Show all 3 Pubmed References
Human Polyclonal JAK2 Primary Antibody for IHC - ABIN966432
Feener, Rosario, Dunn, Stancheva, Myers: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. in Molecular and cellular biology 2004
Show all 2 Pubmed References
Human Polyclonal JAK2 Primary Antibody for FACS, IF - ABIN387982
Joos, Granzow, Holtgreve-Grez, Siebert, Harder, Martín-Subero, Wolf, Adamowicz, Barth, Lichter, Jauch: Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. in International journal of cancer. Journal international du cancer 2002
Show all 5 Pubmed References
Human Monoclonal JAK2 Primary Antibody for ELISA, WB - ABIN969223
Pezet, Buteau, Kelly, Edery: The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. in Molecular and cellular endocrinology 1997
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Human Polyclonal JAK2 Primary Antibody for IF (p), IHC (p) - ABIN740955
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Antibodies) signal.
JAK2 germline mutations coexist with JAK2V617F in Polycythemia vera (show IGF2BP3 Antibodies).
Food intake had minimal impact on the pharmacokinetics of JAK2 inhibitor fedratinib. The tolerability of this drug was improved when taken following a high-fat breakfast.
The JAK2 V617F and non-V617F mutations have a diagnostic sensitivity of 98% to 100% for Polycythemia Vera (show IGF2BP3 Antibodies). This means that the presence of a JAK2 mutation can be used as a clonal marker to distinguish Polycythemia Vera (show IGF2BP3 Antibodies) from reactive secondary causes of Erythrocytosis.
STIP1 (show STIP1 Antibodies) modulates the function of the HSP90 (show HSP90 Antibodies)-JAK2-STAT3 (show STAT3 Antibodies) complex
Decreased expression of JNK2 (show MAPK9 Antibodies) in T24 cells conferred resistance to cell death induced by mitomycin C
JAK2(V617F) mutation is associated with myelofibrosis.
the frequencies of mutations from JAK2 wild-type to JAK2V617F and vice versa increased following erythroid differentiation
we report that the recipient and the donor JAK2 46/1 haplotypes are significantly associated with aGvHD grades II-IV in AML (show RUNX1 Antibodies) patients undergoing allo-HSCT.
our studies suggest that the JAK2(V617F)-bearing ECs form an important component of the myeloproliferative neoplasms vascular niche and contribute to mutant stem/progenitor cell expansion, likely through a critical role of the TPO (show THPO Antibodies)/MPL (show MPL Antibodies) signaling axis.
Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (show STAT3 Antibodies) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (show STAT3 Antibodies) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (show CISH Antibodies) interacted with phosphorylated EpoR (show EPOR Antibodies) at Y401, which was critical for the activation of STAT5 (show STAT5A Antibodies) and ERK (show EPHB2 Antibodies).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (show CBL Antibodies)(mut (show MUT Antibodies)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (show TFEB Antibodies) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (show EZH2 Antibodies) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (show EZH2 Antibodies) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (show EZH2 Antibodies)
findings demonstrate that clinically relevant doses of the JAK1 (show JAK1 Antibodies)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies)-AKT (show AKT1 Antibodies) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Antibodies) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Antibodies) and mTOR (show FRAP1 Antibodies) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Antibodies) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase