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Human JAK2 Primary Antibody for IHC - ABIN966430
Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. in Molecular and cellular biology 2004
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Human Monoclonal JAK2 Primary Antibody for ELISA, WB - ABIN966429
Mol, de Rijke, Demacker, Stalenhoef: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. in Atherosclerosis 1997
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Human JAK2 Primary Antibody for IHC - ABIN966431
Feener, Rosario, Dunn, Stancheva, Myers: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. in Molecular and cellular biology 2004
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Human Polyclonal JAK2 Primary Antibody for FACS, IF - ABIN387982
Joos, Granzow, Holtgreve-Grez, Siebert, Harder, Martín-Subero, Wolf, Adamowicz, Barth, Lichter, Jauch: Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. in International journal of cancer. Journal international du cancer 2002
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Human Monoclonal JAK2 Primary Antibody for ELISA, WB - ABIN969223
Pezet, Buteau, Kelly, Edery: The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. in Molecular and cellular endocrinology 1997
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Human Polyclonal JAK2 Primary Antibody for IF (p), IHC (p) - ABIN740955
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Human Polyclonal JAK2 Primary Antibody for IF (p), IHC (p) - ABIN742853
Liao, Hu, Guo, Zhang, Xu, Jiang: Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway. in Molecular medicine reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Antibodies) signal.
Our findings revealed that B7-H3 (show CD276 Antibodies) affect ovarian cancer progression through the Jak2/Stat3 (show STAT3 Antibodies) pathway, indicating that B7-H3 (show CD276 Antibodies) has the potential to be a useful prognostic marker.
In 136 patients with myelofibrosis and a median age of 58 years who underwent allogeneic stem cell transplantation (AHSCT) for molecular residual disease, the percentage of molecular clearance on day 100 was higher in CALR (show CALR Antibodies)-mutated patients (92%) in comparison with MPL (show MPL Antibodies)- (75%) and JAKV617F-mutated patients (67%).
Mutational subtypes of JAK2 correlate with different clinical features in Japanese patients with myeloproliferative neoplasms.
identification of activating somatic mutations in JAK2 and germline mutations in JAK3 (show JAK3 Antibodies) with clinical implications
Amorfrutin A also inhibited activation of the upstream kinases Janus-activated kinase 1 (JAK1 (show JAK1 Antibodies)), JAK2 and Src (show SRC Antibodies) signaling pathways.
findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1 (show VCAM1 Antibodies)-coated surfaces
Screening for the JAK2 V617F mutation in cerebral venous thrombosis patients seems to be useful because of its relatively high prevalence and the risk of thrombosis recurrence.
Ascochlorin significantly decreased phosphorylation of JAK2/STAT3 (show STAT3 Antibodies), cancer cell migration and nuclear translocation of STAT3 (show STAT3 Antibodies).
TLR7 (show TLR7 Antibodies), TLR9 (show TLR9 Antibodies), and JAK2 genes are potential biomarkers for systemic sclerosis. High TLR7 (show TLR7 Antibodies) expression positively correlated with the late form of disease. Decreased levels of TLR9 (show TLR9 Antibodies) and JAK2 mRNA were found in the patient's cohort in comparison to non-SSc (show CYP11A1 Antibodies) individuals.
Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta (show IL1B Antibodies) by inhibiting the aggregation of NALP1 (show NLRP1 Antibodies) inflammasome and the activation of the JAK2-STAT3 (show STAT3 Antibodies) cascade in astrocytes.
Results demonstrate that JAK2 deficiency delays tumor formation in GH-transgenic mice, which is linked to insignificant oncogenic STAT3 (show STAT3 Antibodies) signaling and reduced reactive oxygen species-induced oxidative damage.
Reg3g (show REG3g Antibodies) acts as an immunosuppressive promoter by activating the JAK2/STAT3 (show STAT3 Antibodies) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
High JAK2 expression is associated with skeletal muscle wasting in cancer cachexia.
Data (including data from studies in knockout mice) suggest that various tissues utilize Jak2 signaling to regulate insulin (show INS Antibodies), glucose, and lipid metabolism; adipocyte Jak2 appears to regulate hepatic insulin (show INS Antibodies) resistance in mechanism independent of adiposity (obesity), liver lipid content (non-alcoholic fatty liver disease), and hepatic insulin (show INS Antibodies) signaling.
Advanced glycation end products induce apoptosis and inflammation in mouse podocytes through CXCL9 (show CXCL9 Antibodies)-mediated JAK2/STAT3 (show STAT3 Antibodies) pathway activation.
Cilostazol protects MIR (show MLXIP Antibodies) injury by activating a PPARgamma (show PPARG Antibodies)/JAK2/STAT3 (show STAT3 Antibodies) pathway.
These results suggest that JAK2 regulated the microfilaments aggregation during the mouse oocyte maturation.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (show STAT3 Antibodies) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (show STAT3 Antibodies) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (show STAT3 Antibodies) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (show CISH Antibodies) interacted with phosphorylated EpoR (show EPOR Antibodies) at Y401, which was critical for the activation of STAT5 (show STAT5A Antibodies) and ERK (show EPHB2 Antibodies).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies)-AKT (show AKT1 Antibodies) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Antibodies) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Antibodies) and mTOR (show FRAP1 Antibodies) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Antibodies) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase