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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
The results suggested that HGF (show HGF Proteins) may inhibit TEMT (show INMT Proteins) by inhibiting AngII through the JAK2/STAT3 (show STAT3 Proteins) signaling pathway in HK2 (show HK2 Proteins) cells and HGF (show HGF Proteins) may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT (show INMT Proteins) by HGF (show HGF Proteins), which requires further investigation
Clinical features of JAK2V617F- or CALR (show CALR Proteins)-mutated essential thrombocythemia and primary myelofibrosis.
NGS may be useful to identify a minority of Polycythemia vera (show IGF2BP3 Proteins) and essential thrombocythemia patients with high genetic instability and increased risk of acute myeloid leukemia (show BCL11A Proteins) transformation.
IL-10 (show IL10 Proteins) from M2 macrophage promoted proliferation of glioma through interaction with JAK2.
JAK2 germline mutations coexist with JAK2V617F in Polycythemia vera (show IGF2BP3 Proteins).
Food intake had minimal impact on the pharmacokinetics of JAK2 inhibitor fedratinib. The tolerability of this drug was improved when taken following a high-fat breakfast.
The JAK2 V617F and non-V617F mutations have a diagnostic sensitivity of 98% to 100% for Polycythemia Vera (show IGF2BP3 Proteins). This means that the presence of a JAK2 mutation can be used as a clonal marker to distinguish Polycythemia Vera (show IGF2BP3 Proteins) from reactive secondary causes of Erythrocytosis.
STIP1 (show STIP1 Proteins) modulates the function of the HSP90 (show HSP90 Proteins)-JAK2-STAT3 (show STAT3 Proteins) complex
Decreased expression of JNK2 (show MAPK9 Proteins) in T24 cells conferred resistance to cell death induced by mitomycin C
JAK2(V617F) mutation is associated with myelofibrosis.
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (show STAT3 Proteins) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (show STAT3 Proteins) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (show CISH Proteins) interacted with phosphorylated EpoR (show EPOR Proteins) at Y401, which was critical for the activation of STAT5 (show STAT5A Proteins) and ERK (show EPHB2 Proteins).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (show CBL Proteins)(mut (show MUT Proteins)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (show TFEB Proteins) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (show EZH2 Proteins) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (show EZH2 Proteins) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (show EZH2 Proteins)
findings demonstrate that clinically relevant doses of the JAK1 (show JAK1 Proteins)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase