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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (show IFNG Proteins) signal.
The authors discovered tyrosine 78 of Atoh1 (show ATOH1 Proteins) is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog (show SHH Proteins)-type medulloblastoma.
conclude that the activating JAK2 V617F mutation does not play a decisive role in the pathogenesis of progressive CKD
Our findings revealed that B7-H3 (show CD276 Proteins) affect ovarian cancer progression through the Jak2/Stat3 (show STAT3 Proteins) pathway, indicating that B7-H3 (show CD276 Proteins) has the potential to be a useful prognostic marker.
In 136 patients with myelofibrosis and a median age of 58 years who underwent allogeneic stem cell transplantation (AHSCT) for molecular residual disease, the percentage of molecular clearance on day 100 was higher in CALR (show CALR Proteins)-mutated patients (92%) in comparison with MPL (show MPL Proteins)- (75%) and JAKV617F-mutated patients (67%).
Mutational subtypes of JAK2 correlate with different clinical features in Japanese patients with myeloproliferative neoplasms.
identification of activating somatic mutations in JAK2 and germline mutations in JAK3 (show JAK3 Proteins) with clinical implications
Amorfrutin A also inhibited activation of the upstream kinases Janus-activated kinase 1 (JAK1 (show JAK1 Proteins)), JAK2 and Src (show SRC Proteins) signaling pathways.
findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1 (show VCAM1 Proteins)-coated surfaces
Screening for the JAK2 V617F mutation in cerebral venous thrombosis patients seems to be useful because of its relatively high prevalence and the risk of thrombosis recurrence.
Ascochlorin significantly decreased phosphorylation of JAK2/STAT3 (show STAT3 Proteins), cancer cell migration and nuclear translocation of STAT3 (show STAT3 Proteins).
Results demonstrate that JAK2 deficiency delays tumor formation in GH-transgenic mice, which is linked to insignificant oncogenic STAT3 (show STAT3 Proteins) signaling and reduced reactive oxygen species-induced oxidative damage.
Reg3g (show REG3g Proteins) acts as an immunosuppressive promoter by activating the JAK2/STAT3 (show STAT3 Proteins) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
High JAK2 expression is associated with skeletal muscle wasting in cancer cachexia.
Data (including data from studies in knockout mice) suggest that various tissues utilize Jak2 signaling to regulate insulin (show INS Proteins), glucose, and lipid metabolism; adipocyte Jak2 appears to regulate hepatic insulin (show INS Proteins) resistance in mechanism independent of adiposity (obesity), liver lipid content (non-alcoholic fatty liver disease), and hepatic insulin (show INS Proteins) signaling.
Advanced glycation end products induce apoptosis and inflammation in mouse podocytes through CXCL9 (show CXCL9 Proteins)-mediated JAK2/STAT3 (show STAT3 Proteins) pathway activation.
Cilostazol protects MIR (show MLXIP Proteins) injury by activating a PPARgamma (show PPARG Proteins)/JAK2/STAT3 (show STAT3 Proteins) pathway.
These results suggest that JAK2 regulated the microfilaments aggregation during the mouse oocyte maturation.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (show STAT3 Proteins) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (show STAT3 Proteins) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (show STAT3 Proteins) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (show CISH Proteins) interacted with phosphorylated EpoR (show EPOR Proteins) at Y401, which was critical for the activation of STAT5 (show STAT5A Proteins) and ERK (show EPHB2 Proteins).
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins)-AKT (show AKT1 Proteins) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (show STAT5A Proteins) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.
SNPs in JAK2 and STAT5B (show STAT5B Proteins) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase