anti-Human JAK3 antibody for ELISA

Recommended JAK3 Antibody (supplied by: Log in to see )

Antigen
Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • fae
  • wil
  • RATJAK3
  • JAK
  • Janus kinase 3
  • JAK3
  • Jak3
Epitope
AA 1-620
19
18
15
15
10
8
7
7
7
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
117
71
53
2
2
2
2
2
1
Host
Mouse
88
34
1
Clonality
Monoclonal
Conjugate
This JAK3 antibody is un-conjugated
5
5
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA
74
49
27
25
19
15
11
9
8
7
1
1
1
1
Options
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Catalog No. ABIN393714
$ 461.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.625677 ABIN1327344 ELISA Mouse IgG2a kappa AA 1-619, full length Log in to see 1E10 0
11.625677 ABIN517291 ELISA Mouse IgG2a kappa AA 1-619, full length Log in to see 3F10 0
1 ABIN1532701 IF IHC ELISA WB Rabbit IgG AA 751-800 Log in to see Polyclonal 1
1 ABIN4327888 ELISA FACS ICC IF WB Mouse IgG1 Log in to see 5H2 1
1 ABIN969224 ICC FACS ELISA WB Mouse IgG1 Log in to see 5H2 3
1 ABIN1531677 IHC ELISA WB Rabbit IgG AA 751-800, pTyr785 Log in to see Polyclonal 0
1 ABIN2869455 ELISA FACS ICC WB Mouse IgG1 Log in to see 5H2 3
1 ABIN1844119 ELISA FACS IF/ICC WB Mouse IgG1 Log in to see 0
1 ABIN3185259 ELISA IF IHC WB Rabbit IgG Ser645 Log in to see Polyclonal 0
1 ABIN3182638 ELISA IHC WB Rabbit IgG pTyr785 Log in to see Polyclonal 0
1 ABIN393556 ELISA Mouse IgG2a kappa AA 1-620 Log in to see 2A5 5
1 ABIN5581352 ELISA FACS IF WB Mouse IgG1 Log in to see 5H2 1
1 ABIN517290 ELISA WB Mouse IgG2a kappa AA 1-619, full length Log in to see 2D5 0
1 ABIN5959635 ELISA IF IHC (p) WB Rabbit IgG Tyr785 Log in to see Polyclonal 0
1 ABIN5959636 ELISA IHC (p) WB Rabbit IgG pTyr785 Log in to see Polyclonal 0
1 ABIN2293195 ELISA WB Rabbit IgG N-Term, AA 132-161 Log in to see Polyclonal 0
1 ABIN5618125 ELISA IHC WB Rabbit IgG pTyr785 Log in to see Polyclonal 0
1 ABIN5618126 ELISA IF IHC WB Rabbit IgG Tyr785 Log in to see Polyclonal 0
1 ABIN2293184 ELISA WB APC Rabbit IgG N-Term, AA 132-161 Log in to see Polyclonal 0
1 ABIN2293178 FACS ELISA WB Mouse IgG1 Log in to see 13B433 0

General

Antigen Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
Epitope AA 1-620
(19), (18), (15), (15), (10), (8), (7), (7), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human
(117), (71), (53), (2), (2), (2), (2), (2), (1)
Host Mouse
(88), (34), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This JAK3 antibody is un-conjugated
(5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application ELISA
(74), (49), (27), (25), (19), (15), (11), (9), (8), (7), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-JAK3 Antibody

Target Details JAK3 Application Details Handling References for anti-JAK3 antibody (ABIN393714) Images
Specificity JAK3 (AAH28068, 1 a.a. ~ 620 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: JAK3 (AAH28068, 1 a.a. ~ 619 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 3F10
Isotype IgG2a kappa
Plasmids, Primers & others

Target Details JAK3

Product Details anti-JAK3 Antibody Application Details Handling References for anti-JAK3 antibody (ABIN393714) Images back to top
Antigen
Alternative Name JAK3 (JAK3 Antibody Abstract)
Background

Other Names: Tyrosine-protein kinase JAK3, Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK, JAK3

Gene Description: Janus kinase 3 (a protein tyrosine kinase, leukocyte)

Gene Summary: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq

Molecular Weight 125099 DA
Gene ID 3718
NCBI Accession NP_000206
UniProt P52333
Pathways JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded protein response

Application Details

Product Details anti-JAK3 Antibody Target Details JAK3 Handling References for anti-JAK3 antibody (ABIN393714) Images back to top
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Restrictions For Research Use only

Handling

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details References for anti-JAK3 antibody (ABIN393714) Images back to top
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References for anti-JAK3 antibody (ABIN393714)

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling Images back to top
Background publications

Kameda, Shide, Shimoda, Hidaka, Kubuki, Katayose, Taniguchi, Sekine, Kamiunntenn, Maeda, Nagata, Matsunaga, Shimoda: "Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma." in: International journal of hematology, Vol. 92, Issue 2, pp. 320-5, 2010

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Lotz, Knutsen: "Janus kinase 3 missense mutation in a child with Jacobsen syndrome." in: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Vol. 104, Issue 6, pp. 536-7, 2010

Chrencik, Patny, Leung, Korniski, Emmons, Hall, Weinberg, Gormley, Williams, Day, Hirsch, Kiefer, Leone, Fischer, Sommers, Huang, Jacobsen, Tenbrink, Tomasselli, Benson: "Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6." in: Journal of molecular biology, Vol. 400, Issue 3, pp. 413-33, 2010

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010

Images

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling References for anti-JAK3 antibody (ABIN393714) back to top
Supplier Images
ELISA image for anti-Tyrosine-Protein Kinase JAK3 (JAK3) (AA 1-620) antibody (ABIN393714) Detection limit for recombinant GST tagged JAK3 is approximately 3 ng/mL as a capture...
ELISA image for anti-Tyrosine-Protein Kinase JAK3 (JAK3) (AA 1-620) antibody (ABIN393714) Detection limit for recombinant GST tagged JAK3 is approximately 3ng/ml as a capture ...