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identification of activating somatic mutations in JAK2 (show JAK2 Proteins) and germline mutations in JAK3 with clinical implications
we report the results of a screening for mutations in SETBP1 (show SETBP1 Proteins) and JAK3 of a cohort of seventy Italian patients with juvenile myelomonocytic leukemia, identifying 11.4% of them harboring secondary mutations in these two genes and discovering two new mutations in the SKI (show SKI Proteins) domain of SETBP1 (show SETBP1 Proteins)
Jak3-mediated phosphorylation of beta-catenin (show CTNNB1 Proteins) suppressed EGF (show EGF Proteins)-mediated epithelial-mesenchymal transition and facilitated epithelial barrier functions by AJ localization of phosphorylated beta-catenin (show CTNNB1 Proteins) through its interactions with alpha-catenin (show CTNNA1 Proteins).
frequency of JAK3 mutations in the JH2 domain was relatively low in extranodal natural killer/T-cell lymphoma, nasal type (NTCL) in contrast to a previous report; study identified novel JAK3H583Y- and JAK3G589D-activating mutations that were oncogenic and sensitive to a JAK3 inhibitor
In natural killer/T-cell lymphoma (NKTL) as a disease model, phosphorylation of EZH2 (show EZH2 Proteins) by JAK3 promotes the dissociation of the PRC2 complex leading to decreased global histone H3 (show HIST3H3 Proteins) lysine 27 methylation levels.
a causal relationship between MLH1 (show MLH1 Proteins)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
JAK3 mediates smooth muscle cell proliferation and survival during injury-induced vascular remodeling.
Data indicate that phosphorylation of Janus kinase 3 (JAK3) and STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) was inhibited by latent membrane protein 1 (LMP1 (show PDLIM7 Proteins))-IgG.
analysis of JAK3 kinetic mechanism and inhibition by tofacitinib
patient had a homozygote of the JAK3 mutation, and her parents were heterozygous carriers.
Blockade of JAK1 (show JAK1 Proteins)-JAK3 accelerated, and selective inactivation of STAT3 (show STAT3 Proteins) decelerated differentiation of progenitor cells.
Study investigated the effect of Jak3 signaling on differentiation from nestin (show NES Proteins) progenitor cells using E13.5 spinal progenitor cell cultures. Results indicated that neuronal and microglial cell differentiation was regulated primarily by Jak3 signaling and the developing neurons and neurite outgrowth might also be regulated by Jak3-dependent microglial activity.
Small-scale in vivo screening identified several genes, including Cd109 (show CD109 Proteins), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (show STAT3 Proteins) as a critical, pharmacologically targetable effector of CD109 (show CD109 Proteins)-driven lung cancer metastasis
JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and JAK3 are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
JAK3 up-regulates SGLT1 (show SLC5A1 Proteins) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.
This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 kinase activity in IL-2 (show IL2 Proteins)-driven T cell proliferation.
Experiments implicate JAK1 (show JAK1 Proteins)/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.
Foxp3 (show FOXP3 Proteins) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (show STAT1 Proteins) pathway
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 (show FOXO1 Proteins) from the nucleus to the cytoplasm.
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
, leukocyte Janus kinase
, tyrosine-protein kinase JAK3
, Janus kinase 3 protein-tyrosine kinase
, Janus kinase 3, protein-tyrosine kinase
, Janus tyrosine kinase